# FUNCTIONAL ANALYSIS OF SLEEP HOMEOSTASIS IN DROSOPHILA

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 2020 · $344,258

## Abstract

Although the precise function of sleep remains unknown, there is little question that
sleep is required for maintaining optimal performance in a large and diverse number of
biological systems. Indeed, cognitive impairments associated with aging and
neurodegenerative disorders are frequently accompanied by deficits in sleep physiology
and architecture. We have previously shown that enhanced sleep can reverse memory
deficits even in flies with catastrophic lesions to their primary memory center. We have
now mapped a minimal circuitry required by this memory assay. Using genomics and
behavioral genetics we have identified genes that can restore memory when they are
modulated in a single circuit-component in a similar fashion as that produced by sleep.
In this proposal we will determine the molecular pathways that regulate these genes. In
addition, we will use calcium imaging to determine how restoring a single circuit
component modulates the activity of other circuit components to restore memory during
brain damage or the expression of Human Alzheimer's' related genes.

## Key facts

- **NIH application ID:** 9902560
- **Project number:** 5R01NS051305-16
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** PAUL J SHAW
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $344,258
- **Award type:** 5
- **Project period:** 2005-04-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9902560

## Citation

> US National Institutes of Health, RePORTER application 9902560, FUNCTIONAL ANALYSIS OF SLEEP HOMEOSTASIS IN DROSOPHILA (5R01NS051305-16). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9902560. Licensed CC0.

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