# Administrative Core

> **NIH NIH P42** · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2020 · $76,696

## Abstract

ADMINISTRATIVE CORE SUMMARY 
The UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund 
Research Program (SRP) and Training Center will focus on risk reduction for Native Americans exposed to 
hazardous mixtures of metals from abandoned uranium mines. The specific theme of the UNM METALS center 
is elucidation of how exposures to metal mixtures from uranium mining wastes result in DNA damage and 
immune dysregulation. The Center has a particular focus on how these exposure:outcome relationships are 
manifested in Tribal populations throughout the West who carry much of the burden of these exposures with 
only minimal understanding of their impacts. The biomedical research proposed in UNM METALS focuses on 
major uncertainties in these outcomes, while environmental projects seek to complement this research by 
improving understanding of the mineralogic and biogeochemical environment that impacts mobility, toxicity and 
remediation, and by testing novel metals immobilization strategies that may reduce risks long term. 
Recognizing that complete remediation of these sites under CERCLA remains decades away, METALS will 
use multi-directional community engagement and research translation cores to develop and implement trans- 
generational approaches to risk communication and risk avoidance that integrate indigenous learning models 
and Western science. The METALS Center will integrate training of junior faculty and graduate students with 
multi-directional training of community members and research staff so that local knowledge of mining impacts 
and health problems inform air and water monitoring needed to support the environmental and biomedical 
research projects. The Administrative Core will provide the coordination and oversight to ensure overall 
operational and scientific integration of the team, to ensure scientific integrity to promote linkage among the 
projects both scientifically and professionally, to facilitate integration of goals with community needs, and to 
enable effective translation of findings to the communities impacted through the following four Specific Aims: In 
Specific Aim 1 we will coordinate communication among project and core leaders to ensure scientific progress, 
to discuss and address issues and to disseminate relevant information and significant findings. In Specific Aim 
2 we will ensure effective research translation and communication with community members and other 
stakeholders. In Specific Aim 3 we will administer pilot research funding opportunities for members of the UNM 
METALS team. Lastly, in Specific Aim 4 we will provide financial oversight, facilitate resource support and 
ensure regulatory compliance related to research and community activities associated with the Center. The 
Administrative Core will also ensure that all compliance requirements of sponsors, research institutions and 
community partners are met. The Core will also work to expand transdisciplinary c...

## Key facts

- **NIH application ID:** 9903348
- **Project number:** 5P42ES025589-04
- **Recipient organization:** UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- **Principal Investigator:** Johnnye L Lewis
- **Activity code:** P42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $76,696
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9903348

## Citation

> US National Institutes of Health, RePORTER application 9903348, Administrative Core (5P42ES025589-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9903348. Licensed CC0.

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