# MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)

> **NIH NIH U01** · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · 2020 · $2,962,160

## Abstract

Project Summary/Abstract
Despite the availability of ever more potent antiretroviral therapy, the struggle to optimize the health of HIV-
infected men and women continues, as they suffer and die from premature medical co-morbidities including
cardiovascular, pulmonary disease, neurocognitive dysfunction and malignancies. The goal of the Chicago Cook
County Clinical Research Site (CRS) of the MACS/WIHS Combined Cohort Study, formerly the Chicago
Women's Interagency HIV Study, is to advance understanding of HIV-related co-morbidities and pathogenesis
through scientific innovation and a translational approach involving investigators from basic, clinical,
behavioral and community health sciences. In collaboration with the other national Clinical Research Sites and
the Data Analysis and Coordinating Center, the site has developed a Unified Science Agenda that aims to
holistically describe mechanisms underlying premature morbidity and mortality in HIV-infected persons. Cook
County CRS investigators will lead or co-lead projects in Behavioral Science, Malignancy, Neurocognition,
Sleep Science and Pathogenesis including initiatives related to Liver Disease, Oral Health, Microbiome Science
and Outcome Adjudication. The Cook County CRS will contribute to HIV and multidisciplinary science by
fostering collaboration through an open, inquisitive approach, sharing ideas and the rich data and specimen
resources of the cohort with qualified experts who can further advance mechanistic understanding of HIV-
associated co-morbidities. The Cook County CRS will also support promising and diverse early career
investigators and those new to HIV research through pilot grants, intentional mentorship, and linkage to
resources to support independent funding. Finally, through expansive engagement of cohort participants and
community partners, the Cook County CRS will rapidly disseminate key study findings and obtain insight into
the most pressing issues for Chicagoans affected by HIV to inform future scientific direction.

## Key facts

- **NIH application ID:** 9903477
- **Project number:** 5U01HL146245-02
- **Recipient organization:** HEKTOEN INSTITUTE FOR MEDICAL RESEARCH
- **Principal Investigator:** Mardge H Cohen
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,962,160
- **Award type:** 5
- **Project period:** 2019-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9903477

## Citation

> US National Institutes of Health, RePORTER application 9903477, MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS) (5U01HL146245-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9903477. Licensed CC0.

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