# Feasibility Testing of a Microphone System to Facilitate Patient Communication During Noninvasive Ventilation

> **NIH NIH R43** · AXON MEDICAL, INC. · 2020 · $224,225

## Abstract

PROJECT SUMMARY/ABSTRACT
This Phase 1 SBIR proposal focuses on improving communication between clinicians and patients undergoing
noninvasive ventilation (NIV) for acute respiratory failure. Noninvasive ventilation in hospital settings is life-
saving and highly effective, but it requires use of a mask that covers the nose and mouth obstructing speech.
This mask severely limits patient communication. Because of this lack of communication, patients often report
feeling they are unable to speak up about their care needs, suffer high levels of anxiety, and may suffer more
delirium. An innovative NIV accessory (the ReddyPort Oral Access Elbow) has introduced access into the NIV
mask utilizing a large one-way valve. Using this FDA-approved valve, a microphone can be placed into the
mask to allow a patient to freely communicate using their voice without interrupting NIV. In this grant, we
propose the improvement and testing of a voice amplification system consisting of a microphone module that is
placed into the mask through the ReddyPort Oral Access Elbow and that connects to a bedside speaker that
amplifies the voice. We plan to improve systems for voice intelligibility including improving the microphone
module, introducing a breathing noise cancellation system, and designing a system for naturalizing the
patient's voice. We will then test this system on both volunteers and patients to further iterate the device and
perfect the systems for improving speech intelligibility.
In a subsequent Phase II, the device will be tested in a clinical trial powered for efficacy endpoints including
anxiety, engagement, and delirium. Axon's team has demonstrated commercial success with several devices
and looks forward to bringing this device through regulatory approvals to commercialization in order to reduce
patient anxiety and improve engagement during the life-threatening illness of acute respiratory failure.

## Key facts

- **NIH application ID:** 9904380
- **Project number:** 1R43HL147788-01A1
- **Recipient organization:** AXON MEDICAL, INC.
- **Principal Investigator:** Lara M Brewer
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $224,225
- **Award type:** 1
- **Project period:** 2020-07-01 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9904380

## Citation

> US National Institutes of Health, RePORTER application 9904380, Feasibility Testing of a Microphone System to Facilitate Patient Communication During Noninvasive Ventilation (1R43HL147788-01A1). Retrieved via AI Analytics 2026-06-16 from https://api.ai-analytics.org/grant/nih/9904380. Licensed CC0.

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