# Functional Genomics, Proteomics, and Metabolomics Facility Core

> **NIH NIH P30** · UNIVERSITY OF WASHINGTON · 2020 · $343,999

## Abstract

ABSTRACT
The goal of the Functional Genomics, Proteomics, and Metabolomics Facility Core (FGPM-FC) is to enable
Center affiliates to integrate state-of-the-art genomics, transcriptomics, epigenetics, proteomics and
metabolomics methods into their research in a cost effective manner. It is well established that chemical
exposure of biological systems results in expression changes of numerous RNA and protein molecules and
these changes are correlated with, and are indicative of toxicity. In addition, many molecular epidemiologic
studies have identified correlations between genetic polymorphisms and incidence of environmental-related
disease. Toxicological monitoring increasingly involves the assessment of genetic and other molecular
measurements derived from individuals and sentinel animals, to detect markers of disease susceptibility and to
identify early indicators of chemical effect, such as alterations in gene expression profiles due to exposure to
environmental toxicants. Various targeted molecular methods as well as OMICs based approaches have been
developed in recent years and continue to develop rapidly. These methods complement each other and allow
for mechanistic investigations of entire biological pathways and networks, as well as their individual
components. The optimal application of these state-of-the-art methodologies requires considerable expertise in
a) sample preparation and processing, b) generation and quality assessment of the data, c) rigorous statistical
and bioinformatics analysis, d) as well as interpretation of the complex data sets. Most investigators do not
have the financial resources or specialized expertise to keep up with the rapid technological advancements.
However, it is critical for investigators to have access to the latest technologies in order to be competitive and
to perform cutting edge research. The Functional Genomics, Proteomics and Metabolomics Facility Core
(FGPM-FC) together with the Bioinformatics and Biostatistics Unit (BBU) of the Integrative Environmental
Health Sciences Facility Core (IEHS-FC) address these challenges. It provides expertise in genomics,
transcriptomics, epigenetics, proteomics and metabolomics based methods that support the study of gene-
environment interactions in the context of environmental health sciences research and population-based
studies.

## Key facts

- **NIH application ID:** 9904625
- **Project number:** 5P30ES007033-25
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Jing Zhang
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $343,999
- **Award type:** 5
- **Project period:** — → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9904625

## Citation

> US National Institutes of Health, RePORTER application 9904625, Functional Genomics, Proteomics, and Metabolomics Facility Core (5P30ES007033-25). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9904625. Licensed CC0.

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