# Omics and Bioinformatics Facility Core

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $177,582

## Abstract

ABSTRACT (Omics and Bioinformatics Core)
Applications of next generation sequencing, protocols for targeted omics assays, and the number and breadth
of publicly-available omics datasets all continue to expand at a rapid pace. As such, it is difficult for
environmental health scientists to stay up-to-date on all of the technologies, analysis methods, and available
data relevant to their research. The objective of the Omics & BioInformatics Core (OBIC) is to provide
comprehensive and innovative support to investigators in the Michigan Center on Lifestage Environmental
Exposures and Disease (M-LEEaD) for the study design, sample preparation, analysis, interpretation, and
integration of a broad range of omics-based studies, and to educate them on available opportunities. OBIC
streamlines the entire process of an omics study, allowing center investigators to dedicate more of their own
resources to answering difficult environmental health science questions. Lifestage environmental exposures
may increase the risk of later disease through a variety of molecular mechanisms, including epigenetic,
genetic, transcriptomic, and metabolomics mechanisms. Technologies for which we provide expertise and
analysis include pyrosequencing and Sequenom, RNA-seq, gene expression and DNA methylation
microarrays, microRNA expression, HumanMethylation450 BeadChip, reduced representation bisulfite
sequencing (RRBS) and MeDIP-seq, and ChIP-seq. The OBIC objective will be accomplished through four
specific aims. First, we will provide M-LEEaD investigators expertise in the design and implementation of a
broad range of omics and gene target studies (e.g. genomic, epigenomic, proteomic, metabolomic) and
development of protocols, including technology platform choice, and sample collection and preparation.
Second, we will provide M-LEEaD investigators with a broad-range of bioinformatics analysis services,
including standard or custom analyses, support for data management and visualization, and pathway/network
analyses. Third, OBIC supports the community through development of novel bioinformatics methods and tools
and protocols for novel technologies staying apace with technological advancements. Finally, OBIC educates
center faculty, staff, and students on omics assays and bioinformatics methods most relevant to environmental
health sciences research, and connects environmental scientists with potential collaborators in omics and
bioinformatics. M-LEEaD investigators benefit from free and/or reduced cost services. Our services include
assistance in grants and manuscript preparation, individual training on the use of tools and resources, and
Bioinformatics/Omics workshops targeted to M-LEEaD investigators.

## Key facts

- **NIH application ID:** 9904649
- **Project number:** 5P30ES017885-09
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Maureen Agnes Sartor
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $177,582
- **Award type:** 5
- **Project period:** — → 2022-06-15

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9904649

## Citation

> US National Institutes of Health, RePORTER application 9904649, Omics and Bioinformatics Facility Core (5P30ES017885-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9904649. Licensed CC0.

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