# Sources, Transport, Exposure and Effects of PFASs (STEEP)

> **NIH NIH P42** · UNIVERSITY OF RHODE ISLAND · 2020 · $94,433

## Abstract

CORE SUMMARY/ABSTRACT
The URI-led STEEP (Sources, Transport, Exposure and Effects of PFASs) proposes to aid the Superfund
Research Program (SRP) in addressing the emerging and expanding problem of poly- and perfluorinated alkyl
substances (PFASs) contamination. PFASs are industrial compounds that have been manufactured since the
1950s for use in myriad products due to their unique oil and water repellent properties. The environmental
dissemination and the human health effects have only begun to be characterized over the previous decade.
Thus, U.S. Environmental Protection Agency limits for PFASs contamination of drinking water remain
provisional since first published in 2009. Also, in the recently released 2015 draft ToxProfile, the Agency for
Toxic Substances and Disease Registry (ATSDR) stressed a number of uncertainties as to PFASs human
health impacts and therefore disregarded recent reports on adverse human health effects at PFASs exposures
commonly occurring in the U.S. Thus, the need for improved risk characterization is urgent.
 The Administrative Core (AC) is the central hub of STEEP, integrated with the rest of center through the
Director’s role in active STEEP Project research and communication, and runs the day-to-day management of
Core activities. Its main role is to ensure STEEP runs well and produces integrated science, training,
communication, and engagement of benefit to SRP and stakeholders. STEEP will be led by Rainer Lohmann,
Ph.D., Center Director (University of Rhode Island, URI) and Philippe Grandjean, M.D., D.M.Sc, Center Co-
Director (Harvard University, HU), who will provide center integration, vision, and effective leadership. They will
be supported by Frank Baker (URI), Center Manager, who will oversee the day-to-day operation and workings
of the Center. The AC will be guided by an Internal Advisory Committee (IAC) on a bimonthly basis, and by an
External Advisory Committee (EAC) annually as part of a full-day retreat.
 URI is committed to the success of the URI STEEP Center and will fund a faculty appointment in a
related emerging contaminants field to further strengthen Center expertise, support the Center Manager, fund
2 additional minority graduate student assistantships and funds to support additional graduate student
activities. URI STEEP will organize the Fall 2020 URI Honors Colloquium focusing on emerging contaminants
with access for the academic community and the public.
 The AC will fulfill its commitment to ensure the success of the URI-led STEEP through the following
Specific Aims:
Specific Aim 1: Create a STEEP organization that responds in a timely fashion to opportunities,
challenges, and evaluations.
Specific Aim 2: Ensure successful integration of Research Projects and Cores through regular
meetings of Project and Core leaders coupled with evaluations from IAC and EAC.
Specific Aim 3: Provide relevant operational insights and tools for stakeholders and communities.

## Key facts

- **NIH application ID:** 9904667
- **Project number:** 5P42ES027706-04
- **Recipient organization:** UNIVERSITY OF RHODE ISLAND
- **Principal Investigator:** Rainer Lohmann
- **Activity code:** P42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $94,433
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9904667

## Citation

> US National Institutes of Health, RePORTER application 9904667, Sources, Transport, Exposure and Effects of PFASs (STEEP) (5P42ES027706-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9904667. Licensed CC0.

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