# Metabolism and Toxicity Core

> **NIH NIH P42** · UNIVERSITY OF LOUISVILLE · 2020 · $297,551

## Abstract

ABSTRACT
The function of the Metabolism and Toxicity Core is to provide intellectual input, high quality analytical services
and validated data in support of all projects in this Superfund Center. Furthermore, its support and interaction
with all other components of this Center will assure the overall success of these endeavors. While it is charged
to satisfy the existing needs of the current projects, the scope of the Core services will not be limited to the
requirements of these projects. The Core will endeavor to develop leading edge technologies and use them to
establish a variety of validated endpoints including exposure biomarkers, disease prognosticators and
therapeutic interventions. This Core will be comprised of three discrete technology-centric components, including
Flow Cytometry, Metabolism and Pathology that nevertheless will function seamlessly and efficiently together to
ensure that the projects progress smoothly. In addition, this Core will strive to educate and train its users through
technical seminars and hands-on operation. It will also organize informal meetings which will serve as forums
for bringing together users to initiate discussion of novel procedures, applications and approaches. Finally, the
Metabolism and Toxicity Core intends to expand its operations, not only to support the multidimensional needs
of the proposed projects, but also to facilitate interactions with additional UofL faculty investigators and with other
Superfund Centers. Thus the highly diverse, yet integrated services and expertise of this Core are essential to
achieve the goals of the Superfund center and help make progress with regards to understanding the likely
diverse pathological consequences of VOC exposures and the mitigation of these consequences.

## Key facts

- **NIH application ID:** 9904683
- **Project number:** 5P42ES023716-04
- **Recipient organization:** UNIVERSITY OF LOUISVILLE
- **Principal Investigator:** Timothy E O'Toole
- **Activity code:** P42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $297,551
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9904683

## Citation

> US National Institutes of Health, RePORTER application 9904683, Metabolism and Toxicity Core (5P42ES023716-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9904683. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*