# COBRE in Stroke Recovery

> **NIH NIH P20** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2020 · $2,240,864

## Abstract

The overall goal of this Phase II COBRE is to enable outstanding multidisciplinary collaborative research in
recovery from stroke. Stroke recovery research is especially important to South Carolina, because a
disproportionate rate of stroke incidence statewide results in undue economic, social and personal burdens from
post-stroke disability. Our organizing concept is that increased understanding of the experience-dependent
nature of neural plasticity will allow us to investigate and exploit inherent neural recovery processes, develop
and translate novel mechanism-based interventional strategies, and ultimately improve the function and quality
of life of individuals recovering from stroke. The specific aims are to: 1) Expand the critical mass of funded
investigators conducting stroke recovery research; 2) Strengthen innovative scientific cores that support stroke
recovery research; and 3) Advance the ongoing development of an independent, sustainable, multidisciplinary
thematic research program. A collaborative partnership continues to drive the COBRE in Stroke Recovery
Center, composed of a PhD biomedical engineer/biomechanical scientist as Program Director and Principal
Investigator, and an MD/clinical stroke expert as Associate Program Director, coalescing resources and
disciplines from two distinct health professional schools, the College of Medicine and the College of Health
Professions, at the Medical University of South Carolina. This COBRE has four scientific cores: 1) The
Quantitative Behavioral Assessment & Rehabilitation Core provides standardized experience and quantitative
measurement of behavior and function. 2) The Brain Stimulation Core provides a plasticity-modifying adjuvant
for treatment and quantitative measurement of plasticity and neurophysiology. 3) The Neuroimaging Core
provides quantitative measurement of plasticity and structural and functional connectivity. 4) The Clinical &
Translational Tools and Resources Core provides access to the tools and resources necessary for innovative
research with human subjects, including development of Comprehensive Multidisciplinary Database (CMD) in
collaboration with MUSC’s CTSA that will be a novel research portal to support research and data sharing. Four
new Junior Investigators (JIs) have been competitively selected for Phase II. Each is investigating an important
aspect of stroke recovery using a suite of measurement tools rarely found in stroke recovery research settings.
Key innovative features of this COBRE include: (a) the interprofessional, multidisciplinary expertise of the core
leaders and Junior Investigators; (b) integration of motion capture and clinical assessment tools, brain stimulation
tools, neuroimaging tools, and resources for biostatistics and data sharing applied to stroke recovery research;
and (c) a comprehensive multiple source mentoring approach to prepare the JIs as future leaders in
clinical/translational research in recovery from stroke. Extensive institu...

## Key facts

- **NIH application ID:** 9904699
- **Project number:** 5P20GM109040-07
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** STEVEN A. KAUTZ
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,240,864
- **Award type:** 5
- **Project period:** 2014-06-02 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9904699

## Citation

> US National Institutes of Health, RePORTER application 9904699, COBRE in Stroke Recovery (5P20GM109040-07). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/9904699. Licensed CC0.

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