# OMICS CORE

> **NIH NIH P20** · UNIVERSITY OF LOUISVILLE · 2020 · $326,169

## Abstract

High-throughput 'omics analysis platforms are the technologies of choice for analyzing complex mixtures
derived from tissues and biological matrices such as liver, feces, intestine, blood and urine. To maximize our
capability for deciphering the mechanism and therapy for liver injury, nutrition and gut:liver interactions, and
liver:environment/toxin/drug interactions, we propose an OMICS Core in this Hepatobiology and Toxicology
COBRE proposal. Our OMICS Core is composed of three major components including Metabolomics Core,
Proteomics Core, and Bioinformatics. The overarching goal of the OMICS Core is to support the proposed
COBRE research. This goal will be met through application of state of the art separations science and mass
spectrometry techniques to analyze research samples containing complex mixtures of metabolites, proteins
and protein fragments. This goal is achieved through the following aims:
Specific Aim 1: Application of liquid chromatography mass spectrometry (LC-MS), comprehensive two-
dimensional gas chromatography time-of-flight mass spectrometry (GCxGC/TOF-MS) and integrated laser
ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) platforms for quantitative analysis of
metabolites, metal ions, and metal-protein complex in biological samples.
Specific Aim 2: Application of high-resolution multidimensional liquid chromatography mass spectrometry
(MDLC-MS) and affinity enrichment methods for targeted protein quantification.

## Key facts

- **NIH application ID:** 9904702
- **Project number:** 5P20GM113226-05
- **Recipient organization:** UNIVERSITY OF LOUISVILLE
- **Principal Investigator:** Xiang Zhang
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $326,169
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9904702

## Citation

> US National Institutes of Health, RePORTER application 9904702, OMICS CORE (5P20GM113226-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9904702. Licensed CC0.

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