# ANIMAL MODEL AND BIOREPOSITORY CORE

> **NIH NIH P20** · UNIVERSITY OF LOUISVILLE · 2020 · $124,755

## Abstract

The primary function of Core D is to provide members of the Hepatobiology and Toxicology COBRE with the
expertise, resources and facilities needed for animal husbandry, necropsy and histological services for animal
models of liver disease. The Core provides essential services by addressing the needs of COBRE-supported
junior investigators, COBRE members and other UofL investigators interested in liver disease research. Core
personnel will ensure uniformity of husbandry and phenotyping so that the same set of characteristics is
measured in each model. This uniformity ensures that the data generated within the COBRE are consistent
and that results of one experiment will be directly comparable with the results of another. The Core will isolate
primary hepatic cells (parenchymal, Kupffer, stellate, sinusoidal endothelial cells) for ex vivo and in vitro
studies. The Core will assist COBRE members in developing new mouse models of liver disease. The Core
will also facilitate cataloging and storage of animal and clinical samples in a biorepository that will provide
biobanking infrastructure and support, so that other researchers may share the tissue generated by COBRE-
supported projects. The Core endeavors to contribute to the overall success and utility of the COBRE and to
enhance the infrastructure and the technical and academic capabilities of the institution as a whole. In addition
to its function as a service core, Core D will also promote the education and training of the COBRE members,
with particular attention to the COBRE junior investigators. Core D will specifically communicate with COBRE
junior investigators regarding their experimental requirements on a continual basis and appropriately
participate in the planning, execution and data analysis. To function as a vital integrative component of the
COBRE providing services not only for its members but also for the Institution as a whole, Core D has the
following Specific Aims:
1) To foster the development and success of current and future COBRE projects. 2) To educate and
train investigators.
3) To develop new protocols and techniques:
4) To become an integral and self-sustaining component of the COBRE.

## Key facts

- **NIH application ID:** 9904704
- **Project number:** 5P20GM113226-05
- **Recipient organization:** UNIVERSITY OF LOUISVILLE
- **Principal Investigator:** Gavin E Arteel
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $124,755
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9904704

## Citation

> US National Institutes of Health, RePORTER application 9904704, ANIMAL MODEL AND BIOREPOSITORY CORE (5P20GM113226-05). Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/grant/nih/9904704. Licensed CC0.

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