# Clinical & Translational Tools and Resources (CTTR) Core

> **NIH NIH P20** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2020 · $356,848

## Abstract

The Clinical & Translational Tools and Resources Core (CTTR) is designed to serve the clinical research needs
of COBRE investigators. The centerpiece of the core will be a powerful new research tool, the Stroke
Comprehensive Multidisciplinary Database (CMD). In addition to containing information such as stroke type and
disability status necessary to recruit participants, which comes from the registry established in Phase I called
RESTORE (REgistry for STrOke REcovery), the CMD will be the home of all data produced when an individual
participates in any research study/ies within the COBRE domain. For example, the CMD will include outcome
measures extracted from the data sets collected in the QBAR Core as well as the complete data time series
(e.g., neuromechanical data from behavioral measurements such as gait analyses, neurophysiological data from
transcranial magnetic stimulation protocols in the Brain Stimulation Core, and neuroimaging data from structural
or functional MRI scans in the Neuroimaging Core). The CMD will be a secure, query-enabled research portal
with vast capacity for data sharing accessible to all COBRE investigators. Through a robust interface with the
South Carolina Clinical & Translational Research Institute (SCTR), CTTR has four complementary roles that
represent the core aims: 1) Recruitment & Retention – recruit a large population of well-characterized potential
participants; 2) Biomedical Informatics – continue to develop a secure registry and database providing the ability
to query the pool of participants based on specific characteristics and retrieve an extensive set of multidisciplinary
measures in participants who match the search criteria; 3) Biostatistical Support – provide a strong biostatistical
infrastructure to analyze and mine the rich data set and support experimental design and data analysis; and (4)
Mentoring – enhance the research skills of COBRE investigators to conduct highly translational, mechanism-
based studies in stroke recovery research and neuromodulation. COBRE funds will support the efforts of an
internationally recognized clinician-researcher in the stroke field who serves as Core Director; an expert in
biomedical informatics who oversees the informatics infrastructure; an expert in biostatistical methodologies and
clinical trials development; and technical staff. The SCTR Research Coordinator Core will facilitate research
coordination and recruitment. The integration of multi-source data into the CMD with advanced informatics tools
and biostatistical analyses will provide a unique research resource for future stroke recovery research by: 1)
enabling advanced searches for appropriate candidates for each scientific study by specific characteristics; 2)
providing an avenue for data mining for manuscripts and pilot data generation to increase investigator and trainee
productivity; and 3) embedding biostatistical and data analysis expertise throughout the CMD analyses pipelines.
We envision that C...

## Key facts

- **NIH application ID:** 9904718
- **Project number:** 5P20GM109040-07
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** ROBERT J ADAMS
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $356,848
- **Award type:** 5
- **Project period:** 2014-06-02 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9904718

## Citation

> US National Institutes of Health, RePORTER application 9904718, Clinical & Translational Tools and Resources (CTTR) Core (5P20GM109040-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9904718. Licensed CC0.

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