# Informatics Core

> **NIH NIH P01** · UNIVERSITY OF MINNESOTA · 2020 · $156,357

## Abstract

The function of the Bioinformatics and Data Management Core is to provide the informatics 
infrastructure, analysis tools and specialized expertise required to support the complex data analysis, 
integration and storage needs of this Projects and Cores of this grant. Led by Dr. Sarah Cooley, Director of the 
Masonic Cancer Center Oncology Medical Informatics & Services (OMIS) shared resource, it is composed of 
two teams providing bioinformatics (UK Team; Anthony Nolan Research Institute) and clinical research data 
management support (MN team: OMIS). The two groups will meet in person annually and have 
teleconferences at least every 4 months to ensure the efficient and integrated management of the Core. 
 The MN team is responsible for the development and maintenance of database applications to collect, 
integrate and report research data generated by the projects for subsequent analysis. In addition they will 
support and customize the clinical trials management applications to meet the research and regulatory data 
requirements for the complex (phase I, IND, multi-center) trials in Project 3. The sharing of research samples 
processed and analyzed by Core D will be coordinated through this Core with a customized sample inventory 
management tool. Lastly, this team will ensure data quality, data integrity, and data sharing, in compliance 
with HIPAA regulation and NIH principles. 
 The UK Team will provide bioinformatics support by developing the IPD-KIR Database which will 
facilitate the work of both the global research community and the grant members. They will continue to collect 
and curate the KIR sequence data and provide regular updates of this data to allow further development of the 
typing and sequencing strategies for KIR determination. These developments will include custom 
bioinformatics tools and applications specifically designed to aid research by other grant members. An 
expanded suite of bespoke analysis tools will be imbedded to allow advanced analysis for non- 
Bioinformaticians. A key aim of the IPD project is to provide high quality data that can easily be retrieved and 
used by non-Bioinformaticians. This can be seen in the work of the IMGT/HLA Database where high level data 
files, XML, are available for Bioinformaticians, but also tools with easy to use interfaces are provided to allow 
data analysis possible for a wider range of researchers. They will fully characterize novel KIR sequences 
detected in Project 1 (SA3) and ensure these data are represented in the public database this will be achieved 
by conventional cloning methodologies and employing third generation sequencing strategies on the Pacific 
Biosciences RS II platform. The scientific expertise provided by this team will be invaluable to analyze and 
interpret immunogenetic data.

## Key facts

- **NIH application ID:** 9905397
- **Project number:** 5P01CA111412-15
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** SARAH ANNE COOLEY
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $156,357
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9905397

## Citation

> US National Institutes of Health, RePORTER application 9905397, Informatics Core (5P01CA111412-15). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9905397. Licensed CC0.

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