# Regulation of Alternatiive Cleavage and Polyadenylation

> **NIH NIH R01** · WISTAR INSTITUTE · 2020 · $454,277

## Abstract

PROJECT SUMMARY
Most mammalian genes have multiple cleavage and polyadenylation (C/P) sites, or pAs, resulting in
mRNA isoforms with different coding sequences (CDS) and/or 3' untranslated regions (3'UTRs).
Alternative cleavage and polyadenylation (APA) is rapidly recognized as an important layer of gene
regulation, affecting protein diversity and mRNA metabolism. The APA pattern of genes varies across
cell/tissue types and is dynamically regulated under different conditions, such as proliferation,
differentiation, and in response to extracellular cues. The mechanisms of APA, however, are poorly
understood. Our long-term goal is to understand the `regulatory code' of APA in different cells/tissues
under physiological and pathological conditions and its biological consequences. In this proposal, we
have three specific aims: First, we will examine the role of C/P factors in APA regulation. Second, we
will examine how C/P genes are regulated by APA. Third, we will examine the interplay between
nuclear export and APA. We expect that the result of this grant will provide systematic views on the
mechanisms of APA and shed light on its significance in different cells and tissues, as well as
development and differentiation.

## Key facts

- **NIH application ID:** 9906230
- **Project number:** 7R01GM084089-14
- **Recipient organization:** WISTAR INSTITUTE
- **Principal Investigator:** BIN TIAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $454,277
- **Award type:** 7
- **Project period:** 2008-05-01 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9906230

## Citation

> US National Institutes of Health, RePORTER application 9906230, Regulation of Alternatiive Cleavage and Polyadenylation (7R01GM084089-14). Retrieved via AI Analytics 2026-06-16 from https://api.ai-analytics.org/grant/nih/9906230. Licensed CC0.

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