# Core B: Lipid Mediator-SPM Lipidomics

> **NIH NIH P01** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $268,838

## Abstract

7. Project Summary/Abstract
This Program Project focuses on elucidating the role and actions of novel specialized pro-resolving mediators
(SPM) in acute inflammation and tissue injury. In service to this Program Project to achieve its mission and
goals, this Core, Lipid Mediator-SPM Lipidomics, will provide centralized, standardized and coordinated lipid
mediator (LM) lipidomic profiling procedures for Projects 1-3.
This Core B will execute newly established methods for SPM identification, lipidomics and LM pathway profiling
metabolomics as a central service that will be required routinely by Projects 1-3. Core B will also develop,
validate and implement new lipidomic approaches when needed. By providing a centralized location for the
identification of LM and SPM, their profiling and pathway metabolomics as standardized services, this core
eliminates costly duplication of instruments and personnel within each of the projects.
LM and SPM validation will be carried out by Core B. This core will characterize the physical properties of
synthetic compounds prepared by total organic synthesis in Core C, and shall match these using biophysical
criteria for validation to biologically produced SPM and SPM-sulfido-conjugates (SPM-SC). These will include
resolvins, protectins and maresins, as well as novel bioactive structures recently identified and biosynthetic
pathway isomers, before distributing bioactive synthetic SPM to each project for assessing their functional
roles.
Prioritization of the services and selection of the specific procedures will be determined via individual meetings
with project and core investigators at bimonthly Program Project group meetings to achieve optimal use of
resources and experience of this Core in a cost-effective and timely fashion for the investigators within this
Program Project.

## Key facts

- **NIH application ID:** 9906233
- **Project number:** 5P01GM095467-10
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Charles Nicholas Serhan
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $268,838
- **Award type:** 5
- **Project period:** — → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9906233

## Citation

> US National Institutes of Health, RePORTER application 9906233, Core B: Lipid Mediator-SPM Lipidomics (5P01GM095467-10). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9906233. Licensed CC0.

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