# Core C: Organic Synthesis Core - Total Synthesis of Specialized Pro-Resolving Lipid Mediators

> **NIH NIH P01** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $198,450

## Abstract

7. PROJECT SUMMARY / ABSTRACT
 The Organic Synthesis Core (Core C) will provide essential chemistry support for this research program
through the synthesis and characterization of novel specialized pro-resolving mediators (SPM) and their
sulfido-conjugates (SPM-SC). The Core will be responsible for the total synthesis of a panel of novel SPMs
and related SPM probes, including: resolvins, maresins, sulfido-conjugates, and other related molecules
that will be studied under this program.
 Core C will develop and utilize effective stereocontrolled synthetic pathways for the total synthesis of the
targeted SPM in stereochemically pure form, and establish suitable methods for their detailed purification
and structural verification using spectroscopic techniques. Core C will also prepare needed quantities (up
to mg scale) of selected SPM, and will pursue the design and synthesis of selected derivatives that will
enable their biological investigation. Core C will also prepare isotopically substituted SPM derivatives to
serve as SPM probes for lipidomic profiling in collaboration with Core B and Project 1, 2, and 3, while other
SPM probes will serve as precursors of radiolabelled derivatives for mechanistic studies. Finally, Core C
will collaborate with Projects 1, 2 and 3 and Cores A-B on the proposed studies involving novel biological
actions and cellular mechanisms of SPMs.
 Overall, these collaborative investigations will help elucidate key unexplored functions of SPMs, and will
help validate their functional role(s) in the resolution of inflammation and tissue regeneration.

## Key facts

- **NIH application ID:** 9906234
- **Project number:** 5P01GM095467-10
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** NICOS A PETASIS
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $198,450
- **Award type:** 5
- **Project period:** — → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9906234

## Citation

> US National Institutes of Health, RePORTER application 9906234, Core C: Organic Synthesis Core - Total Synthesis of Specialized Pro-Resolving Lipid Mediators (5P01GM095467-10). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9906234. Licensed CC0.

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