# ShEEP Request for Illumina iScan

> **NIH VA IS1** · PROVIDENCE VA  MEDICAL CENTER · 2020 · —

## Abstract

The responsibility of the Department of Veteran Affairs is to provide excellent medical care to those who
have served their country in the Armed Services. The Office of Research and Development within the
Department of Veteran Affairs is concerned with improving medical care of Veterans through better
understanding of the basic components of disease, the clinical manifestations of conditions requiring medical
treatment, the understanding and improvement of health service delivery, and the science of rehabilitation.
This application requests support for shared instrumentation that provides critical infrastructure to researchers
seeking to improve Veteran health through each of those mechanisms. The research community at the
Providence VA Medical Center has a long history of excellence in each of these domains. From the biological
bases of cardiovascular disease, to the careful characterization of psychopathology, to the Center of
Innovation for Long Term Services, to the outstanding Rehabilitation work for mental and physical disorders
the Providence VAMC has been enormously productive in the area of Veteran-centric medical research.
Consistent with this history of excellence is the requirement for cutting edge research infrastructure to serve
this productive research community. Accordingly, this application requests support for scientific
instrumentation that may further extend the impact and innovation of numerous VA researchers.
 The instrument that we are seeking support for is a microarray reader to replace aging, outdated
technology currently in use. This equipment allows for the assessment of specific genetic and epigenetic
variation in a cost-effective manner. As this machine will replace obsolete equipment (no longer supported by
the manufacturer), it will fit seamlessly into our existing workflows.
 Obtaining this new equipment would position us to complement efforts of the VA-wide Million Veteran
Project (MVP). That is, the MVP relies on the clinical data in CPRS, whereas the PVAMC genomics lab allows
examination of the same kind of genetic variation in samples from those who have participated in controlled
trials. By leveraging the massive MVP observational data with local controlled studies, we increase our
chances of successfully identifying genetic targets that will eventually point to improved therapeutics for our
Veterans. Examples of studies that will benefit from the proposed equipment include Dr. Tracie Shea’s study
of PTSD, Dr. Primack’s studies of suicidality, Dr. Phillip’s study of the neural bases of psychopathology, Dr.
Wu’s study of health service utilization, and numerous other minor users investigating conditions critical for
Veteran health.

## Key facts

- **NIH application ID:** 9907654
- **Project number:** 1IS1BX003984-01A1
- **Recipient organization:** PROVIDENCE VA  MEDICAL CENTER
- **Principal Investigator:** JAMES L RUDOLPH
- **Activity code:** IS1 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2020
- **Award amount:** —
- **Award type:** 1
- **Project period:** 2019-09-01 → 2020-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9907654

## Citation

> US National Institutes of Health, RePORTER application 9907654, ShEEP Request for Illumina iScan (1IS1BX003984-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9907654. Licensed CC0.

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