# Novel Dual Acting Antibiotics for Pulmonary Disease

> **NIH NIH R43** · PARION SCIENCES, INC. · 2020 · $274,173

## Abstract

ABSTRACT
Chronic respiratory disease, hallmarked by recalcitrant airway infection involving mixed bacterial flora combined
with persistent neutrophilic inflammation, is the 3rd leading cause of death in the US and remains a significant
treatment challenge. This application proposes the development of novel, inhaled therapeutic agents to treat the
underlying infection and inflammation in chronic lung diseases. The compound series has a novel bactericidal
mechanism without evidence of resistance and dual anti-inflammatory activity (inhibits neutrophil migration and
cytokine release). The antibiotic activity targets most relevant pathogens in bronchiectasis and potentiates the
activity of aminoglycosides (e.g. tobramycin) for Gram-positive organisms and polymyxins (e.g. Colistin) for
Gram-negatives. Potentiation with Tobramycin improves activity against Gram-positive persister bacteria and
biofilms. Preliminary in vivo safety studies demonstrated pulmonary tolerability after 12 days of administration
(at effective doses), as well as, with IV dosing. This program has the potential to address a significant unmet
need in bronchiectasis and provide new treatment options against the growing threat of antibiotic resistance.

## Key facts

- **NIH application ID:** 9909394
- **Project number:** 1R43AI145766-01A1
- **Recipient organization:** PARION SCIENCES, INC.
- **Principal Investigator:** Karl H Donn
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $274,173
- **Award type:** 1
- **Project period:** 2020-01-27 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9909394

## Citation

> US National Institutes of Health, RePORTER application 9909394, Novel Dual Acting Antibiotics for Pulmonary Disease (1R43AI145766-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9909394. Licensed CC0.

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