# B Cell Renaissance: Epigenetics, Regulation and Immunotherapy

> **NIH NIH R13** · KEYSTONE SYMPOSIA · 2020 · $8,000

## Abstract

ABSTRACT
Support is requested for a Keystone Symposia conference entitled B Cell Renaissance: Epigenetics,
Regulation and Immunotherapy, organized by Drs. Paolo Casali, Nicole Baumgarth, Meinrad Busslinger and
Elizabeth Leadbetter. The conference will be held in Banff, Alberta Canada from March 1-5, 2019.
This conference will bring together experts in B cell biology to discuss the most recent advances in B cell
research from initial development, through maturation, including effector or memory development, until terminal
differentiation. The results of these recent B cells studies are guiding researchers to become more appreciative
of the importance of the molecular changes, including epigenetic marks, modifications and factors that control
and modulate B cell development and differentiation as well as the regulatory forces which influence functional
paths of B cells. The complexities of B cell differentiation pathways through germinal centers and extra-
follicular foci in primary lymphoid organs, in addition to novel interactions in diverse secondary lymphoid
tissues, are also under intense study in both mice and humans. The interactions of B cells with lymphoid cells,
non-lymphoid cells, and secreted factors in a myriad of environments will be covered in conference sessions.
This will help elucidate the numerous factors which influence and ultimately dictate the contribution of each
unique B cell subset to homeostasis, immune defense or immunopathology. Understanding the drivers which
influence B cell differentiation and function will enable precise harnessing of these key elements to optimize
the immuno-therapeutic effect of B cells and their antibodies in autoimmune disease, infection, and cancer.

## Key facts

- **NIH application ID:** 9910328
- **Project number:** 1R13AI149884-01
- **Recipient organization:** KEYSTONE SYMPOSIA
- **Principal Investigator:** Thale Cross Jarvis
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $8,000
- **Award type:** 1
- **Project period:** 2020-02-14 → 2021-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9910328

## Citation

> US National Institutes of Health, RePORTER application 9910328, B Cell Renaissance: Epigenetics, Regulation and Immunotherapy (1R13AI149884-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9910328. Licensed CC0.

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