# Mechanisms of Corneal Nerve Repair

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2020 · $400,844

## Abstract

PROJECT SUMMARY
The cornea is the most densely innervated tissue in humans. Peripheral corneal nerves regenerate follow
injury. Our hypothesis is that VEGF is a critical determinant of corneal nerve regeneration after injury and that
the signaling pathways which mediate neurogenesis are distinct from those which mediate angiogenesis. Aim
1 will characterize the mechanisms by which VEGF ligands mediate corneal nerve repair in vitro and in vivo.
Aim 2 characterizes the ability of VEGF ligands to mediate repair in animal models of corneal injury.

## Key facts

- **NIH application ID:** 9910407
- **Project number:** 5R01EY027912-04
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** Mark I Rosenblatt
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $400,844
- **Award type:** 5
- **Project period:** 2017-05-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9910407

## Citation

> US National Institutes of Health, RePORTER application 9910407, Mechanisms of Corneal Nerve Repair (5R01EY027912-04). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9910407. Licensed CC0.

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