# Higher-Order Chromatin Architecture in Time and Space

> **NIH NIH R13** · KEYSTONE SYMPOSIA · 2020 · $23,400

## Abstract

ABSTRACT
Support is requested for a Keystone Symposia conference entitled Higher Order Chromatin Architecture in
Time and Space, organized by Drs. Jennifer E. Phillips-Cremins, Job Dekker and Stavros Lomvardas. The
conference will be held in Whistler, British Columbia from March 15-19, 2020.
Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs),
subTADs, and looping interactions. As genome-wide chromatin architecture maps become widely available,
the field is shifting focus from mapping to understanding the dynamics of such structures in development, the
cell cycle, and on short time scales in single cells. A critical emerging goal will be to unravel the cause and
effect relationship between genome folding and functions such as transcription, replication, recombination, and
stability/maintenance. There is also a great need to evaluate the organizing principles governing chromatin
topology across many biological conditions and genetic perturbations. Moreover, the role for 3D genome
misfolding in the onset and progression of a wide range of human disease states remains an area of high
interest across multiple disciplines and organ systems. The conference program includes workshops with
topics on leading computational methods to identify biologically relevant patterns in Hi-C data, new genome
mapping and imaging technologies, and new data resources available through the 4D Nucleome consortium.
Finally, the program concludes with a session devoted to novel tools for imaging and engineering the 3D
genome. This Keystone Symposia conference aims to highlight new frontiers across disciplines in tackling the
dynamics and functional roles of the 3D genome in cellular functions across time and space in development
and disease.

## Key facts

- **NIH application ID:** 9910926
- **Project number:** 1R13HG010979-01
- **Recipient organization:** KEYSTONE SYMPOSIA
- **Principal Investigator:** Thale Cross Jarvis
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $23,400
- **Award type:** 1
- **Project period:** 2019-12-21 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9910926

## Citation

> US National Institutes of Health, RePORTER application 9910926, Higher-Order Chromatin Architecture in Time and Space (1R13HG010979-01). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/9910926. Licensed CC0.

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