# Crosstalk between Hedgehog and IGF Signaling in Osteoprogenitors

> **NIH NIH R01** · CHILDREN'S HOSP OF PHILADELPHIA · 2020 · $430,132

## Abstract

Abstract
A fundamental understanding of the molecular mechanism governing adult osteoprogenitors and their
differentiation is essential for developing novel bone anabolic therapeutics. We have recently
discovered that Hh signaling induces expression of Igf signaling components and activates Igf
signaling, thus engaging in a Hh-Igf positive feedabck loop in osteoblast-lineage cells. In addition, we
have identified a Hh-responsive population as critical osteoprogenitors in adult bones. In the current
proposal, we will further elucidate the biochemical basis for the Hh-Igf feedback mechanism, and
explore the physiological relevance of the regulatory loop in postnatal osteoprogenitors and adult
bone formation. Overall, successful completion of this project will provide novel mechanistic insights
about Hh-Igf signaling in adult bones, and may open new avenues for developing effective bone
anabolic therapeutics.

## Key facts

- **NIH application ID:** 9912139
- **Project number:** 5R01DK111212-05
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** Fanxin Long
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $430,132
- **Award type:** 5
- **Project period:** 2018-09-25 → 2021-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9912139

## Citation

> US National Institutes of Health, RePORTER application 9912139, Crosstalk between Hedgehog and IGF Signaling in Osteoprogenitors (5R01DK111212-05). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/9912139. Licensed CC0.

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