# 2020 Cranifacial Morphogenesis and Tissue Regeneration GRC/GRS

> **NIH NIH R13** · GORDON RESEARCH CONFERENCES · 2020 · $23,000

## Abstract

Project Summary
 The ultimate aim of craniofacial research is to understand the causes underlying craniofacial
malformations and to develop diagnostics and therapies for these disorders and for repair of craniofacial tissues.
An in-depth, interdisciplinary understanding of developmental biology, disease processes and tissue repair
provides an essential foundation for insights into the mechanisms of craniofacial morphogenesis and
regeneration and the subsequent translation of scientific outcomes to the clinical management of disorders of
the head and face. Such in-depth work probes the cellular events and molecular switches that control tissue
patterning and repair and the morphogenetic processes that shape craniofacial tissues and organs.
 Contemporary studies of the development of the vertebrate head and face take a multidisciplinary
approach combining developmental biology with functional genomics, biochemistry, biophysics, molecular
biology and cellular biology. As in other fields of developmental biology research, the study of craniofacial
development utilises a range of vertebrate species, including those that are not commonly used for laboratory
studies. Collectively, these provide a range of experimental models for investigating the molecular and cellular
mechanisms underpinning the morphogenesis of craniofacial structures and their associated organs in health
and diseases, as well as offering insights into the evolutionary forces and environmental factors driving the
diversity of form and function of these structures. Research in craniofacial development is a key element of the
discipline of developmental and cell biology and aligns well with the scope of several journals.
 The scientific program will highlight how interdisciplinary research can push boundaries in our
understanding of craniofacial research, through talks investigating the physics and chemistry of craniofacial
biology. Such approaches help researchers address how craniofacial cell populations work together (integration)
and how the surrounding environment impacts on form. This will be accompanied by discussions on how these
processes drive tissue diversity and the form shaping process, and how distinctive features of the vertebrate
head have evolved. Invited presentations by leading researchers will discuss new findings in craniofacial
morphogenesis and repair, with specific focus on the role that mechanics plays in shaping development. The
meeting will also feature sessions on cell signalling, clinical genetics, sense organs, development of new animal
models of craniofacial disorders, and on the applications of tissue engineering strategies for regenerative
craniofacial tissue repair. The programme will bring together researchers of diverse expertise to foster stimulating
discussions and productive collaborations across different fields in a collegial atmosphere.

## Key facts

- **NIH application ID:** 9912417
- **Project number:** 1R13DE029394-01
- **Recipient organization:** GORDON RESEARCH CONFERENCES
- **Principal Investigator:** PAMELA C YELICK
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $23,000
- **Award type:** 1
- **Project period:** 2020-02-10 → 2021-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9912417

## Citation

> US National Institutes of Health, RePORTER application 9912417, 2020 Cranifacial Morphogenesis and Tissue Regeneration GRC/GRS (1R13DE029394-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9912417. Licensed CC0.

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