# Gene-Education Interactions and Psychological Health

> **NIH NIH R21** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $206,250

## Abstract

Project Summary/Abstract
The effect of education on subjective well-being and mental health is an understudied topic, with the existing
literature focusing mostly on how education affects physical health outcomes. The lack of attention to
psychological well-being outcomes is especially surprising given initiatives to use subjective well-being to
supplement or even replace traditional measures of progress and policy evaluation such as GDP and income.
There is a strong association between education and later life mental health and well-being (Cutler and Lleras-
Muney 2006; Deaton and Kahneman 2010), which a necessary but not sufficient condition for a causal relation
running from education to psychological well-being. First, early life health might affect educational attainment. In
addition, third factors such as environmental circumstances and endowed abilities can drive both educational
choices and well-being. Importantly, environmental circumstances and endowments most likely interact in the
production of psychological well-being, so that endowments moderate environmental effects (or vice-versa).
In this exploratory R21, we will investigate how one environmental circumstance interacts with endowed abilities
to produce later life psychological well-being. Specifically, we will study a school reform that exogenously
increased secondary education and test how its well-being effects vary with individual genetic predisposition to
high educational attainment. We define psychological well-being as not only absence of mental illness but also
the presence of positive subjective well-being. We hypothesize that the productivity of schooling investments
depends on genetically determined ability, and that the sign of this relationship varies with the outcome under
study. Heckman et al. (2017), for example, find that while the monetary returns to education are higher for high
ability individuals, the non-monetary benefits, including mental health, are larger for low-ability persons.
We exploit England's Raising of School Leaving Age Order of 1972 as a natural experiment to uncover the
causal effects of education on psychological well-being. This policy increased the minimum school-leaving age
from 15 to 16 years for all students born on or after September 1st 1957, generating a well-documented
discontinuity in education. By comparing the well-being of those born before and after 9/1/1957, we will
investigate whether this extra schooling had an effect on health 35 years later. By testing if these effects vary by
genetic predisposition to education, we can study gene-environment interactions. We will estimate the effects of
education on a number of well-being measures, allowing us to test if education affects different well-being
measures differently. It might increase stress while at the same time improving life satisfaction, for example.
To what extent can educational policy increase life's prospects and improve later life well-being? Are there well-
being di...

## Key facts

- **NIH application ID:** 9912681
- **Project number:** 5R21AG060447-02
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Silvia Helena Barcellos
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $206,250
- **Award type:** 5
- **Project period:** 2019-04-15 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9912681

## Citation

> US National Institutes of Health, RePORTER application 9912681, Gene-Education Interactions and Psychological Health (5R21AG060447-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9912681. Licensed CC0.

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