# Animal Models Facilities Core

> **NIH NIH P30** · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2020 · $164,722

## Abstract

ANIMAL MODELS FACILITIES CORE: PROJECT SUMMARY/ABSTRACT
Animals continue to be important models for the study of molecular mechanisms of complex biological
processes related to environmental exposures. The AMFC provides and maintains genetically engineered mice
that are increasingly being generated to model specific aspects of human diseases and have proven to be
extremely valuable in examining how genetic alterations interact with environmental chemicals and
microorganisms to induce disease. Having personnel with this expertise as well as centralized laboratory
equipment will provide critically important resources for the CEHS. The overall objective of the Animal Models
Facilities Core (AMFC) is to provide Center members with state-of-the-art pathology support, transgenic
resources and a centrally managed AAALAC-accredited animal resource and surgical facility. The Core is
staffed with experienced personnel and is equipped with essential equipment to generate genetically
engineered mice, rederive imported mice by embryo transfer rederivation, provide colony management, utilize
gnotobiotic technology, develop surgical models and prepare and interpret tissue samples by histological and
immunohistochemistry analysis. The CEHS will continue to rely heavily on animal models, particularly
genetically engineered mice (GEM). The models being used by Center members will require extensive
characterization of their tissue phenotypes. Both the technical aspects of obtaining excellent quality sections
and expertise in the identification of pathological changes are essential for the discovery of meaningful genetic
and epigenetic changes that are responsible for the development of lesions. Unfortunately, this histopathologic
expertise is not always available to biomedical research groups and, when absent, can lead to the
misinterpretation of data. Under the direction of Professor Fox, who is boarded in laboratory animal medicine
with 40 years’ experience, and an additional five boarded DVMs and two board certified veterinary pathologists
and a fully staffed diagnostic and histology laboratory, the AMFC will provide essential transgenic, embryo
transfer derivation, colony management, germ free technology, histology, pathology and clinopathologic
services that will enhance the research programs of Center members.

## Key facts

- **NIH application ID:** 9913526
- **Project number:** 5P30ES002109-40
- **Recipient organization:** MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** JAMES G FOX
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $164,722
- **Award type:** 5
- **Project period:** — → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9913526

## Citation

> US National Institutes of Health, RePORTER application 9913526, Animal Models Facilities Core (5P30ES002109-40). Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/grant/nih/9913526. Licensed CC0.

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