# Center for Common Disease Genetics

> **NIH NIH UM1** · BROAD INSTITUTE, INC. · 2020 · $16,668,412

## Abstract

Project Summary Abstract
Building on our 25-year track record in comprehensive genomic studies and addressing
NHGRI's goal for this RFA, we propose to create, apply and test a powerful, reliable and
general strategy for “comprehensive” identification of risk and protective variants that contribute
significantly to any common disease of interest. Toward this end, we will:
 · Create a Common Disease Consortium (CDC) that brings together a collaborative network
of investigators with deep clinical and genetic expertise and >1.1 million well-characterized
samples (cases and controls) across diverse populations, including Europeans, African
Americans, Hispanics and Asians. The CDC will undertake genetic studies under three major
projects related to: (1) Five systemic diseases – early-onset coronary artery disease, type 2
diabetes, inflammatory bowel disease, atrial fibrillation, and stroke; (2) Three severe
neurological disorders – autism, schizophrenia and epilepsy; and (3) Two countries with special
advantages for genetic studies – Finland and Estonia. Through these three projects, the CDC
will explore a range of study designs, population-genetic strategies, genetic architectures, and
diverse populations.
 · Sequence 450,000 samples from the CDC, using the expertise of the Broad Institute's
genomics platform to generate high quality data and to drive down sequencing costs.
 · Analyze the sequence data to elucidate the genetic basis of the diseases, by applying state-
of-the-art methods from in our preliminary studies and developing new methods to increase
power to detect association.
 · Create, disseminate and share data, tools, and resources, to enable the scientific
community to access and analyze genetic studies from the CDC and other sources.

## Key facts

- **NIH application ID:** 9913613
- **Project number:** 3UM1HG008895-04S3
- **Recipient organization:** BROAD INSTITUTE, INC.
- **Principal Investigator:** Mark Joseph Daly
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $16,668,412
- **Award type:** 3
- **Project period:** 2016-01-14 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9913613

## Citation

> US National Institutes of Health, RePORTER application 9913613, Center for Common Disease Genetics (3UM1HG008895-04S3). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9913613. Licensed CC0.

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