# 2020 Notch Signaling in Development, Regeneration, and Diseases GRC/GRS

> **NIH NIH R13** · GORDON RESEARCH CONFERENCES · 2020 · $10,000

## Abstract

Project Summary
The fifth Gordon Research Conference (GRC) on Notch Signaling in Development, Regeneration & Disease
(July 19 – July 23, 2020 at Bates College, Maine) will address a major unmet need in the American scientific
community by convening scientists from both academia and industry around a fundamentally important
developmental signaling pathway broadly relevant to health and disease. Although the first “Notch phenotype”
was described over a century ago, studies elucidating the molecular events responsible for Notch signal
transduction have accelerated since the early 1980s after cloning of the Drosophila Notch receptor gene.
Subsequent studies showed that Notch signaling requires cell-cell contact, established that ligand-induced
proteolysis of the Notch receptor produces a transcriptional regulator that stimulates expression of target
genes, and demonstrated that post-translational modifications are critical to modulate ligand-receptor
interactions. Studies in model organisms identified the importance of Notch signaling in numerous cell fate
decisions. Human genetic studies showed that mutations of core Notch pathway components underlie several
developmental syndromes (e.g. Alagille Syndrome, Spondylocostal Dysostosis, aortic valve disease) and adult
onset diseases (e.g. CADASIL, various heart and valve malformations), while causing or contributing to cancer
initiation or progression in a tissue-dependent manner. Beyond its role in specific organ systems, new findings
have also uncovered a role for Notch in immune, inflammatory and metabolic disorders. Notch-targeted
antibodies and pathway inhibitors have entered clinical trials as potential anti-cancer therapeutics and are
being considered for other indications, but effective deployment of Notch modulators in the clinic continues to
pose distinct challenges around efficacy (what tumors or disease states are most likely to respond), and
toxicity, because of the importance of Notch in the homeostasis of selected adult tissues (such as the gut).
Building on past success, this meeting aims to provide a vibrant US forum to stimulate cross disciplinary
discussions and collaborations in this important area of biology, nurture a sense of community among
researchers, and welcome new members into the field. The meeting program will bring together scientists from
academia, biotech and the pharmaceutical industry addressing fundamental mechanistic, developmental,
clinical and therapeutic questions using cutting-edge approaches. Invited participants include a blend of
established “thought leaders” with vast institutional memory and many early career scientists with exciting new
findings. The informal and confidential environment in GRC meetings encourages free scientific exchange of
unpublished data. The inclusion and integration of a Gordon Research Seminar (GRS) exclusively for postdocs
and graduate students prior to the GRC is a particular asset to draw new scientists into the field and encoura...

## Key facts

- **NIH application ID:** 9913634
- **Project number:** 1R13HD101222-01
- **Recipient organization:** GORDON RESEARCH CONFERENCES
- **Principal Investigator:** Ivan Maillard
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $10,000
- **Award type:** 1
- **Project period:** 2020-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9913634

## Citation

> US National Institutes of Health, RePORTER application 9913634, 2020 Notch Signaling in Development, Regeneration, and Diseases GRC/GRS (1R13HD101222-01). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/9913634. Licensed CC0.

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