# Effects of Sleep Disruption on Subjective Responses to Opioid Administration in Patients with Chronic Pain

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 2020 · $1,038,977

## Abstract

PROJECT SUMMARY/ABSTRACT
 The proposed project investigates the effects of experimental sleep disruption (SD) on opioid response in
males and females with chronic low back pain (CLBP). We propose that SD will alter two primary factors
strongly related to problematic opioid use: 1) measures of opioid abuse liability (self-report indices of “how
high” the drug makes you feel, “drug liking” and the monetary valuation of the drug after acute opioid
administration) and 2) opioid analgesic efficacy. We expect these responses will be more pronounced in
chronic low back pain (CLBP) vs. healthy controls, and in males to a greater extent than females. Our
preliminary data show that SD operates on several intermediate factors associated with both opioid abuse
liability and analgesia, including positive affect, pain sensitivity, and the function of the ventral striatum, the hub
of the brain reward system. Extant literature suggests that CLBP patients may be especially vulnerable to
these effects due to abnormal reward system neurocircuitry. The evaluation of sex differences in these
relationships is essential because males and females evidence different risk profiles with respect to opioid
addiction, sleep problems, and pain. The next step is to directly evaluate the effect of SD on opioid response in
these groups. We propose a within/between design in which male and female participants with CLBP (N=60)
and healthy controls (N=60) will experience both one night of SD and one night of normal sleep, in a random
order. Following each sleep condition, we will evaluate the opioid abuse liability and analgesic efficacy of
hydromorphone, a short-acting synthetic opioid with strong affinity for the μ-opioid receptor, in a placebo-
controlled cumulative dose run-up paradigm. Opioid abuse liability will be assessed with measures of drug
high, liking and the multiple choice procedure, which will measure the monetary valuation of the drug.
Analgesia will be assessed with quantitative sensory testing involving noxious thermal stimuli. We hypothesize
that opioid abuse liability will be augmented and analgesia diminished by SD. We expect those effects to be
stronger in patients with CLBP than healthy controls. Among CLBP patients, we anticipate that males will
evidence greater changes in opioid response following SD than females. This study fills a critical knowledge
gap with major implications for addressing the opioid epidemic. Findings from the proposed study will inform
clinical decision making related to the use of opioids for patients with chronic pain, and may lead to the
development of novel interventions targeting sleep as a means to mitigating problematic opioid use. Data from
the proposed project could lead to subsequent studies designed to determine the extent to which SD-induced
alterations in opioid abuse liability and analgesic efficacy are mediated by putative neurobiological
mechanisms (e.g., striatal function), which could themselves be targeted with phar...

## Key facts

- **NIH application ID:** 9914100
- **Project number:** 5R01DA048206-02
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Patrick Finan
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,038,977
- **Award type:** 5
- **Project period:** 2019-05-01 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9914100

## Citation

> US National Institutes of Health, RePORTER application 9914100, Effects of Sleep Disruption on Subjective Responses to Opioid Administration in Patients with Chronic Pain (5R01DA048206-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9914100. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*