# Cluster A: 3 Radiation and Free Radical Research Core

> **NIH NIH P30** · UNIVERSITY OF IOWA · 2020 · $65,695

## Abstract

The Radiation and Free Radical Research Core (RFRRC) has been in operation since 1947, 
and became a developing HCCC core in 2000. The core progressed to a full HCCC-supported 
shared resource in 2005. It is directed by Dr. Douglas Spitz, who together with co-directors Drs. 
Frederick Domann, Garry Buettner, and Prabhat Goswami, oversees all core operations. All 
have considerable experience and international reputations in free radical-focused cancer 
research. The overall goal of the RFRRC is to provide state-of-the-art technologies to HCCC 
investigators doing both basic and translational studies, encompassing the roles of metabolic 
oxidative stress and redox signaling in cancer biology and therapy. The three basic services 
provided by this shared research resource are: 
1) Ionizing radiation services, phosphorimaging, and cell-cycle analytical tools critical to 
 understanding basic cellular behavior and responses to radiation and chemotherapy. 
2) Electron paramagnetic resonance spectroscopy and other analytical chemistry detection 
 methodologies for measuring free radicals, singlet oxygen, small molecule antioxidants, 
 nitric oxide and the array of related oxidants and oxidative damage products. 
3) Antioxidant enzyme services to provide easy access to technologies for modifying and 
 measuring molecules responsible for pro-oxidant formation and oxidative damage. 
Major equipment available in the RFRRC includes several radiation sources, a Seahorse 
analyzer, various types of spectrophotometers, hypoxia chambers, and equipment for HPLC 
separation and analyte detection. 
The RFRRC provides HCCC members with easy access to specialized knowledge, reagents, 
equipment and resources in a highly collaborative and helpful environment. In the past calendar 
year, 40 HCCC members from all 4 Programs utilized this shared research resource. 
The long term goal of the RFRRC is to continue to facilitate research involving all aspects of 
redox cancer biology in the HCCC (and at other cancer centers nationally) for the purpose of 
developing novel analytic and therapeutic approaches, based on fundamental differences in 
oxidative metabolism in cancer cells.

## Key facts

- **NIH application ID:** 9914241
- **Project number:** 5P30CA086862-20
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** Douglas Robert Spitz
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $65,695
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9914241

## Citation

> US National Institutes of Health, RePORTER application 9914241, Cluster A: 3 Radiation and Free Radical Research Core (5P30CA086862-20). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/9914241. Licensed CC0.

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