# PgLouisville2020: International Conference on P. gingivalis and Related Species

> **NIH NIH R13** · UNIVERSITY OF LOUISVILLE · 2020 · $18,000

## Abstract

ABSTRACT
Recent methodological advances have accelerated research on periodontitis and the role of the dysbiotic
microbiota on the tooth surface below the gum line in the development and maintenance of chronic
inflammation of the periodontium. Concurrently we have learned much about communication between bacteria
in the dental plaque community and how they can corrupt host immune responses. Also our knowledge of
mechanisms causing erosion of the periodontium has increased exponentially. In all respects, Porphyromonas
gingivalis is in the center of the pathobiology of periodontitis. Therefore, the purpose of this meeting is to bring
together specialists investigating different host and bacterial aspects of the disease to present their major
recent achievements. This is essential for continued progress in research into periodontitis and its associated
co-morbidities, since the exchange of ideas will open new avenues in basic studies as well as discoveries of
novel prophylactic and treatment measures. The conference will also serve as a venue to educate PhD
students and postdoctoral associates who have entered this field of research in the most recent major
breakthroughs in periodontitis-related research including: (i) structural and functional characterization of the
novel type IX secretion system (T9SS) used by periodontal pathogens to secrete their proteinaceous virulence
factors; (ii) advances in characterization of virulence factors structure on the atomic structure level
(iii) understanding molecular mechanisms of dysbiotic community development on the tooth surface;
(iv) elucidation of host signaling pathways manipulated by P. gingivalis; (v) implication of P. gingivalis as a
potentially causative factor in such diseases such as esophageal cancer, rheumatoid arthritis and Alzheimer's
disease; and (vi) identification and characterization of new targets for development of novel strategies to
prevent/treat periodontitis.

## Key facts

- **NIH application ID:** 9914613
- **Project number:** 1R13DE029404-01
- **Recipient organization:** UNIVERSITY OF LOUISVILLE
- **Principal Investigator:** JAN S POTEMPA
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $18,000
- **Award type:** 1
- **Project period:** 2020-04-01 → 2022-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9914613

## Citation

> US National Institutes of Health, RePORTER application 9914613, PgLouisville2020: International Conference on P. gingivalis and Related Species (1R13DE029404-01). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/9914613. Licensed CC0.

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