# Molecular Regulation of Mammalian Erythro-Megakaryocytic Development

> **NIH NIH SC1** · CITY COLLEGE OF NEW YORK · 2020 · $392,500

## Abstract

Erythroid (E; red blood cell) and megakaryocytic (M; platelet precursor) lineages are essential and 
vital to vertebrate health and viability as they performing crucial functions like oxygen delivery 
and wound healing. Consequently, relatively minor aberrations in their developmental or  functional programs lead to life threatening disorders. These proclivities are an inevitable fall out of 
the high turnover rate of these cells that makes them acutely susceptible to malfunctions and 
malignancies arising from imbalances  between proliferation and differentiation. These imbalances 
in turn are due to the dysfunctions of various molecular regulators of these processes as evidenced 
by a growing body of data  from  human  patients  and  animal models. The transcriptional 
repressors Gfi1/1b (growth factor independence 1/1b) and their cofactors LSD1 (lysine specific 
demethylase1) and Rcor (REST corepressor)  proteins  have  emerged  over  the  past  several years 
as critical regulators of hematopoiesis. Yet the true  scale  of  their  functions,  and  
mechanistic ramifications of their actions, in E-M development have only been nominally documented. 
Therefore, this proposal focuses on elucidating the collective functions of these transcriptional 
and chromatin regulators and their principal gene/chromatin targets, in orchestrating the ontogeny 
of E-M cells from progenitor (MEP) specification to their divergence and differentiation into 
specialized effector cells. In addition to producing a comprehensive overview of these emergent 
molecular programs and networks in normal development, these insights should also  provide  a  
rational scientific  basis  for  managing  hematopoietic  disorders resulting  from the errant 
activities of these master molecules.

## Key facts

- **NIH application ID:** 9915945
- **Project number:** 5SC1HL136277-04
- **Recipient organization:** CITY COLLEGE OF NEW YORK
- **Principal Investigator:** Shireen Saleque
- **Activity code:** SC1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $392,500
- **Award type:** 5
- **Project period:** 2017-04-06 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9915945

## Citation

> US National Institutes of Health, RePORTER application 9915945, Molecular Regulation of Mammalian Erythro-Megakaryocytic Development (5SC1HL136277-04). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/9915945. Licensed CC0.

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