# Cooperative Human Tissue Network (CHTN)

> **NIH NIH UM1** · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2020 · $764,560

## Abstract

PROJECT SUMMARY / ABSTRACT
The Cooperative Human Tissue Network (CHTN) was established as a mechanism to provide the scientific
community with high quality human tissue biospecimens for cancer research. The CHTN allows investigators
to access the biospecimens they need to perform cutting-edge research, including basic and early translational
cancer research, and assay development.
As one of six CHTN Divisions, the Pediatric Division of the CHTN (pCHTN) will receive, process, and distribute
scientifically-relevant biospecimens collected from children, adolescents, and young adults. These
biospecimens can include malignant, benign, diseased, and uninvolved biospecimens. The pCHTN seeks to
directly promote and support cutting-edge research in the diagnosis and treatment of chronic disease and
cancer by pursuing the following specific aims:
1. To leverage the relationship with the Children’s Oncology Group, in addition to Nationwide Children’s
 Hospital, to procure a wide range of well-annotated biospecimens from a variety of cancers, including
 biospecimens from rare tumor types, and non-cancerous conditions.
2. To support cutting-edge research by distributing high-quality biospecimens to approved investigators.
3. To maximize limited biospecimen resources and provide economies of scale by performing additional
 processing of biospecimens (e.g. nucleic acid extraction, tissue microarrays, digital images of stained
 tissue slides, etc.)
4. To maintain a reliable and robust Quality Management Program that monitors all aspects of biospecimen
 collection, processing, storage, and distribution in an effort to constantly evaluate and improve our
 operational capabilities, assess best practices, ensure investigator satisfaction, and protect the privacy and
 confidentiality of those individuals from whom the biospecimens and data were obtained.
5. To actively contribute to the CHTN by participation and collaboration in trans-Network interactions,
 particularly in fulfilling highly-customized or non-standard requests, participating in collaborative Network
 activities, and coordinating or developing new strategies to ensure that the CHTN remains responsive to
 investigators’ needs.

## Key facts

- **NIH application ID:** 9916741
- **Project number:** 5UM1CA239754-02
- **Recipient organization:** RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- **Principal Investigator:** NILSA DEL CARMEN RAMIREZ MILAN
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $764,560
- **Award type:** 5
- **Project period:** 2019-04-16 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9916741

## Citation

> US National Institutes of Health, RePORTER application 9916741, Cooperative Human Tissue Network (CHTN) (5UM1CA239754-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9916741. Licensed CC0.

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