# Preschooler emotion regulation in the context of maternal borderline personality disorder

> **NIH NIH R01** · UNIVERSITY OF OREGON · 2020 · $820,321

## Abstract

Borderline personality disorder is a serious mental illness characterized by extreme emotions, chaotic
interpersonal relationships, suicidal behaviors, and a poor sense of self. Offspring of mothers with Borderline
Personality Disorder (BPD) are at an elevated risk for developing mental illness across the lifespan. Difficulty
managing emotions are a hallmark feature of BPD, and yet the ability to do so is necessary for responding
effectively to childrens' emotions. This process is called maternal emotion socialization, which has a major
impact on how children develop their own emotion regulation (ER) skills. ER develops rapidly during preschool
and deficits in preschool ER are recognized as underlying future mental disorders. This proposal will test a
model examining the extent to which maternal ER and emotion socialization impact child ER, which may be a
significant pathway by which mental health problems are transmitted to offspring of mothers with BPD. This
proposal will leverage Dialectical Behavior Therapy (DBT) Skills training, a robust and effective method for
improving ER as a tool to change maternal ER in mothers with BPD. By completing multiple assessments of
biobehavioral markers of child and mother ER, this study is poised to uncover a potentially modifiable pathway
by which these offspring are at risk. Specifically, we propose to conduct a stratified randomized controlled trial
of DBT Skills for mothers with BPD who have preschoolers. A total of 300 dyads (initial child age: 36-48
months) will be collected in Eugene, Oregon and Pittsburgh Pennsylvania, with 100 pairs in each of three
groups: children who have mothers with BPD who receive DBT Skills, children who have mothers with BPD
who receive Family Services as Usual, and children who have non-disordered mothers, matched on income,
with this final group only participating in assessments (as to quantify normative ER growth). All children will be
assessed 4 times every 4-months, with the first assessment occurring prior to treatment assignment. We will
use a biobehavioral laboratory battery to measure child ER, assessing emotion understanding, strategy use,
attention regulation and inhibitory control, and parasympathetic regulation. In mothers, we will employ a similar
multi-method approach to assess emotion acceptance, strategy use, recognition, and parasympathetic
regulation. Finally, during each laboratory assessment, we will observe mother's ability to effectively respond to
children in the context of child negative emotions. Growth curve modeling will chart child ER trajectories for all
3 groups so that we can compare child ER growth as a function of: group status (DBT Skills vs. Family
Services as Usual vs. income matched, non-disordered controls), changes in maternal ER, and changes in
maternal emotion socialization. Findings from this proposal will identify a modifiable pathway by which offspring
of mothers with BPD are at risk, determine the extent to which child ER can be ...

## Key facts

- **NIH application ID:** 9918460
- **Project number:** 5R01MH111758-04
- **Recipient organization:** UNIVERSITY OF OREGON
- **Principal Investigator:** Maureen Zalewski
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $820,321
- **Award type:** 5
- **Project period:** 2017-05-01 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9918460

## Citation

> US National Institutes of Health, RePORTER application 9918460, Preschooler emotion regulation in the context of maternal borderline personality disorder (5R01MH111758-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9918460. Licensed CC0.

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