# Science Core B

> **NIH NIH P01** · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2020 · $547,169

## Abstract

Project Summary / Abstract
Our broad, long-term objectives are to supply reagents, models and expertise from a centralized Science Core
facility to all participants of the Program. Core operation represents a balance between providing services
based on established procedures, and continued innovation in methods and protocols. Safety is a particular
guiding principle of the Core, and is are addressed by the many years of experience of Core participants in the
study of TSEs, facilities for safe homogenization and other biohazard operating procedures, prion handling and
decontamination. Protocol standardization is another crucial goal, so that all aspects of the Program have
access to reagents and services produced and operated using consistent methods from a constant, reliable
source. Specific Aims: Aim I - To supply purified recombinant PrP for assays to quantify prions, and for
analyses of PrP conversion; Aim II - To supply purified anti-PrP monoclonal antibodies (mAbs) with well-
defined properties; Aim III - To supply characterized transgenic and gene targeted mouse models; Aim IV - To
quantify prions using sensitive, high throughput cell-based assays; and Aim V - To provide a variety of services
to analyze pathological consequences of prion infection. The Science Core resides in outstanding
environments for studies of prion diseases. Studies within individual Projects will be conducted in close
collaboration with the Science Core to take advantage of the availability of models and expertise, standardized
and consistent methodologies, and uniformly consistent, high quality reagents. The activity of the Core is
essential for the successful accomplishment of Program goals.

## Key facts

- **NIH application ID:** 9920662
- **Project number:** 5P01AI077774-10
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- **Principal Investigator:** Glenn C Telling
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $547,169
- **Award type:** 5
- **Project period:** — → 2022-03-10

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9920662

## Citation

> US National Institutes of Health, RePORTER application 9920662, Science Core B (5P01AI077774-10). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9920662. Licensed CC0.

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