# Oregon Alzheimer's Disease Research Center

> **NIH NIH P30** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $3,030,040

## Abstract

Project Summary: Overall
The overarching goal of the Oregon Alzheimer’s Disease Research Center (OADRC) is twofold: (1) to focus on
early detection of change in order to define mechanisms supporting healthy brain aging and the transition to
MCI and early dementia, and (2) to facilitate developing effective therapies to prevent or limit these transitions.
To achieve these objectives, eight cores and a Research Education Component are organized to catalyze and
sustain innovative research and discovery in Alzheimer Disease and related dementias (ADRD) through an
organizational infrastructure that supports a rich collaborative environment composed of leading edge
technologies and methods, multi-disciplinary scientists, empowered research volunteers, and an inspired
community of lay and professional stakeholders. The OADC provides the necessary materials to support
research through well-characterized research participants, biological specimens, brain tissue, data provision
and analytics. The OADRC focuses on specific areas of emphasis: 1) Preclinical dementia and activity of
disease emphasizing the oldest old; 2) Markers of meaningful change captured through studies of peripheral
biomarkers, neuroimaging and continuous in-home behavioral monitoring; 3) Neuropathology of brain aging
and late life dementia; 4) Novel testing of novel treatments, and 5) Improving education and sharing knowledge
about dementia.
To attain these goals and objectives, the OADRC Specific Aims are to:
1. Catalyze and sustain innovative research and discovery in Alzheimer Disease and related disorders through
 an organizational infrastructure supporting a rich collaborative environment composed of leading edge
 technologies and methods, multi-disciplinary scientists, empowered research volunteers, and an inspired
 community of lay and professional stakeholders.
2. Focus the innovation and discovery infrastructure of the center toward specific areas of emphasis: (1)
 Preclinical dementia and activity of disease emphasizing the oldest old; (2) Markers of meaningful change
 captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral
 monitoring; (3) Neuropathology of brain aging and late life dementia; (4) Novel testing of novel treatments;
 and (5) Improving education and knowledge about dementia.
3. Provide the necessary materials to support the science through well-characterized research participants,
 biological specimens, brain tissue, data provision and analytics.
4. Contribute to the national research commons relevant to Alzheimer’s disease and related disorders.
5. Provide venues and mechanisms for education and training of new scientists, as well as educating and
 informing key stakeholders such as clinicians, patients and diverse family members to address the
 challenges of dementia.

## Key facts

- **NIH application ID:** 9922085
- **Project number:** 1P30AG066518-01
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** JEFFREY A KAYE
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $3,030,040
- **Award type:** 1
- **Project period:** 2020-07-01 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9922085

## Citation

> US National Institutes of Health, RePORTER application 9922085, Oregon Alzheimer's Disease Research Center (1P30AG066518-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9922085. Licensed CC0.

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