# Core B-Clinical Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA-IRVINE · 2020 · $617,520

## Abstract

Core B: Clinical Core
Project Summary/Abstract
The UCI ADRC Clinical Core enrolls, characterizes and follows a cohort of individuals who are cognitively
unimpaired, cognitively impaired, or demented, each of whom complete the Uniform Data Set (UDS) consisting
of physical and neurological exams and a battery of neurocognitive assessments. In addition to this UDS,
participants and their study partners complete questionnaires and assessments unique to our ADRC, and
voluntarily contribute a variety of tissue and biomarker assessments, including genetic analyses, volumetric
imaging, cerebrospinal fluid analyses, and donation of fibroblasts for the generation of induced pluripotent stem
cells (iPSC). Overall, 292 of our current 330 active participants have donated fibroblasts or peripheral blood
mononuclear cells (PBMCs), which have been used to generate 192 iPSC lines by our iPSC Core. Most
participants agree to brain donation at autopsy and we have a high rate of successful completion of autopsy
confirmation at death. Our UDS cohort currently includes 330 active participants. Among this cohort, 60% are
female and one third are non-White race or Hispanic ethnicity. Nineteen percent are demented, 18% meet
criteria for Mild Cognitive Impairment (MCI), and a majority (60%) do not meet diagnostic criteria for MCI or
dementia. Our overall retention rates are very high and above the median for the ADRC system. Most UDS
participants have been enrolled in externally funded ancillary studies, ranging from telephone interview studies
to neuroimaging biomarker research. To support the increasing needs of ADRC investigators, including novel
studies of molecular and vascular biomarkers, we will grow this UDS cohort to a steady state n=400, with an
emphasis on enrolling individuals who enable novel studies in support of the UCI ADRC theme “to identify,
quantify, and validate factors that influence the risk of AD across the lifespan.”!

## Key facts

- **NIH application ID:** 9922101
- **Project number:** 1P30AG066519-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** CLAUDIA H. KAWAS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $617,520
- **Award type:** 1
- **Project period:** 2020-06-15 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9922101

## Citation

> US National Institutes of Health, RePORTER application 9922101, Core B-Clinical Core (1P30AG066519-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9922101. Licensed CC0.

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