# Core F: Induced Pluripotent Stem Cell Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA-IRVINE · 2020 · $274,604

## Abstract

Core F: Induced Pluripotent Stem Cell Core
Project Summary/Abstract
Genome wide association studies have identified almost 30 genes that are associated with altered risk of
developing late-onset Alzheimer's disease (AD). Yet, precisely how those genes impact the function of human
cells to either promote or protect against the development or progression of AD remains unclear. One
promising approach that is increasingly being used to examine such questions involves the use of induced
pluripotent stem cells (iPSCs), which can be generated from control and AD subjects and then differentiated
into the key brain cells implicated in AD. In 2013, the UCI Alzheimer's disease research center (ADRC)
became the first ADRC to establish an induced Pluripotent Stem Cell (iPSC) Core. Since then, the core has
generated and provided iPSC lines from AD, MCI and control subjects to researchers around the world who
are using these lines to examine the impact of AD genes on human cellular function. In the current application,
the iPSC Core will continue to embrace new advances in AD genetics and CRISPR gene editing to generate
and distribute additional highly unique iPSC lines from UCI's three ADRC cohorts (UDS, DS, and 90+).
Through five specific aims, the iPSC Core will collaborate with AD researchers worldwide (Aims 1-5), employ
innovative genetic studies and genome engineering to facilitate the study of genetic AD risk factors in late-
onset AD and specialized AD populations (Aims 1, 3, 4), and educate the research and lay communities about
the scientific applications and implications of AD iPSCs (Aim 5).

## Key facts

- **NIH application ID:** 9922105
- **Project number:** 1P30AG066519-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** Mathew Mark Blurton-Jones
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $274,604
- **Award type:** 1
- **Project period:** 2020-06-15 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9922105

## Citation

> US National Institutes of Health, RePORTER application 9922105, Core F: Induced Pluripotent Stem Cell Core (1P30AG066519-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9922105. Licensed CC0.

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