# Computation

> **NIH NIH P41** · JACKSON LABORATORY · 2020 · $358,717

## Abstract

PROJECT SUMMARY/ABSTRACT - COMPUTATION COMPONENT
The Computation Component of the Gene Expression Database (GXD) project supports GXD by maintaining
its sophisticated informatics infrastructure. GXD is a rich resource of mouse developmental gene expression
data through which researchers can discover expression patterns crucial for understanding the function of
genes and the molecular mechanisms that underlie human development, health, and disease. The GXD
infrastructure maintained by the Computation Component contains relational databases, data loading and QC
software components, an interactive curatorial interface, and a modern web interface. We will evolve the
system to enable the new functionality described in the Curation and Technical Development Components.
This will include (1) enhancing the representation of mouse anatomy to encompass developmental
differentiation and expression in specific cell types; (2) develop structures to support the indexing of high
throughput sequencing (HTS) expression datasets and the loading of selected baseline datasets; (3)
enhancing computational access to GXD with a powerful web service API; and (4) maintaining the GXD
system infrastructure through regular maintenance and coordinated upgrades. In achieving these aims, we will
apply industry best practices such as agile development methods, automatic regression testing, regular
maintenance schedules, and comprehensive quality control measures.
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## Key facts

- **NIH application ID:** 9922142
- **Project number:** 5P41HD062499-10
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** James A Kadin
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $358,717
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9922142

## Citation

> US National Institutes of Health, RePORTER application 9922142, Computation (5P41HD062499-10). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9922142. Licensed CC0.

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