# Sex differences in effects of genetics & GxE interactions on elderly cognition, mental health and survival

> **NIH NIH P01** · DUKE UNIVERSITY · 2020 · $465,140

## Abstract

This competing revision Project focus on investigating the sex difference in effects of genetics & GxE
interactions on elderly cognition, mental health and survival. Analyses will be based primarily on
genotype/phenotype data from the Chinese Longitudinal Healthy Longevity Surveys (CLHLS), with replications
and comparisons using available datasets from U.S. Health and Retirement Survey (HRS) and Singapore Han
Chinese Health Study (SCHS). We aim to contribute to future health promotion programs considering male and
female individual differences in genetic characteristics, in order to increase the efficiency of the interventions.
 The Aims of our interdisciplinary research are: (1) Identify sex-specific genetic variants significantly
associated with cognition, mental health and survival at old ages, using CLHLS data. (2) Investigate sex
differences in the effects of genetic variants identified in Aim (1) and GxE interactions on cognition, mental
health and survival at old ages, using the CLHLS data. (3) International replicative/comparative analyses of
genetic and GxE effects on cognition, mental health and longevity at old ages. We will use available GWAS
and survey datasets from HRS and SCHS to replicate/compare the significant findings based on the CLHLS
data (Aims (1)-(2)), to understand cross country and ethnic similarities and differences. (4) Develop an
integrated CLHLS genotype/phenotype database for healthy aging studies which will represent the world’s
largest samples of male and female centenarians, nonagenarians and other ages. The de-identified CLHLS
genotypic/phenotypic data will be deposed in the NIH dbGaP program for other scholars’ research.

## Key facts

- **NIH application ID:** 9922229
- **Project number:** 5P01AG031719-10
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** YI ZENG
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $465,140
- **Award type:** 5
- **Project period:** — → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9922229

## Citation

> US National Institutes of Health, RePORTER application 9922229, Sex differences in effects of genetics & GxE interactions on elderly cognition, mental health and survival (5P01AG031719-10). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9922229. Licensed CC0.

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