# Network for Investigation of Delirium across the U.S. (NIDUS)

> **NIH NIH R24** · HEBREW REHABILITATION CENTER FOR AGED · 2020 · $730,052

## Abstract

Delirium, an acute disorder of attention and cognition, is a common, life-threatening, and potentially
preventable clinical syndrome in older persons. Given its adverse impact on functioning and quality of life,
delirium holds tremendous healthcare and societal implications for the individual, family, community, and
healthcare systems. Despite its importance, fundamental advances in diagnosis, pathophysiology, and
treatment have been lagging and there is a compelling need for more effective approaches to advance the
field. Responding to RFA-AG-16-009, we propose the development of a collaborative research network,
NIDUS (Network for Investigation of Delirium across the U.S.), to advance scientific discovery through a
purposeful, coordinated effort. Our specific aims are: (1) To create and maintain a database that will catalog
elements and provide an efficient platform to enhance the sharing of data and biospecimens both within and
outside the proposed network, facilitating multi-site collaboration, secondary analyses, and pilot studies to
catalyze the field; (2) To develop a repository of core measures for delirium identification, diagnosis, and
severity, and to harmonize data across all types of delirium studies; (3) To support pilot studies to encourage
innovative research, targeted to priority areas (risk factors/prognosis; pathophysiology/biomarkers; diagnostic
tools/phenomenology; and clinical interventions); (4) To mentor junior investigators interested in delirium
research through training programs, educational resources, and integration into network activities; (5) To
disseminate information on research resources, data sharing, training opportunities, and potential
collaborations in a timely and effective manner to relevant stakeholders and to the broader scientific
community. These synergistic aims will leverage the accumulated research expertise of over 28 delirium
leaders (12 coinvestigators/Steering Committee and 16 Scientific Advisory Board members) across 27
institutions (who have committed in-kind support), to create the NIDUS collaborative network. NIDUS will
provide a research infrastructure with 2 Resource Cores to provide: (1) a catalog of research resources/
databases and (2) a repository of core delirium measures. These will be augmented with 3 Task Forces
providing: (1) pilot grants, (2) mentorship and career development support, and (3) dissemination of
information through many approaches (e.g., scientific symposia, annual meetings, and social media). NIDUS
will create a unique national resource that will facilitate and catalyze innovation in delirium research through
providing core resources and training, targeting priority areas, promoting collaboration across disciplines and
institutions, engaging and mentoring junior investigators across fields, and disseminating research findings
broadly and effectively. Bringing together diverse multidisciplinary perspectives, including patient/family
perspectives, holds great potenti...

## Key facts

- **NIH application ID:** 9922845
- **Project number:** 5R24AG054259-05
- **Recipient organization:** HEBREW REHABILITATION CENTER FOR AGED
- **Principal Investigator:** SHARON K. INOUYE
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $730,052
- **Award type:** 5
- **Project period:** 2016-09-30 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9922845

## Citation

> US National Institutes of Health, RePORTER application 9922845, Network for Investigation of Delirium across the U.S. (NIDUS) (5R24AG054259-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9922845. Licensed CC0.

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