# Animal Models & Phenotyping Core

> **NIH NIH P30** · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2020 · $274,595

## Abstract

D. Abstract (Animal Models & Phenotyping Core)
During the past 10 years (Y1-5 and Y6-10 of funding), the mandate of the Animal Models and Phenotyping
Core (AMPC) was to make high quality transgenic and gene knockout mouse production and metabolic and
behavioral phenotyping readily accessible, both technically and financially, to NORC members. The Animal
Models and Phenotyping Core (AMPC) is comprised of two interactive components: the Animal Models
Subcore and the Energy Metabolism and Behavioral Subcore. THE AMPC provides services that combined
controlled manipulation of gene expression in mice with state-of-the-art in vivo metabolic phenotyping and
detailed behavioral analysis. Over the past two funding cycles (Y1-5, Y6-10), the APMC has been a key
component of the overall mission of the Pennington NORC to stimulate new and innovative research related to
nutrition and obesity. The aims of the core are as follows: Aim 1: To utilize transgenic and gene targeting
techniques to generate mouse models that mimic human disease states, such as obesity and insulin
resistance, when exposed to an obeseogenic environment (sedentary lifestyle and high caloric diets). Aim 2:
To conduct detailed in vivo metabolic phenotyping to assess measures of physiologic function such as, energy
expenditure, fat accumulation, food intake, and metabolic flexibility. Aim 3: Conduct in vivo experiments for
detailed analysis of animal behavior so as to support NORC members and the Pilot and Feasibility Program.
Aim 4: Pursue new methods and experimental paradigms based on observations from NORC members and
Pilot and Feasibility experiments. The above Aims will be performed using a combination of genetic and other
in vivo approaches. Experiments in which the genetic constitution can be changed to study the role of specific
genes on obesity and diabetes cannot be performed in humans. These studies will identify mechanisms that
act on the progression of metabolic dysfunction (i.e., insulin resistance, ectopic fat deposition, metabolic
inflexibility, pancreatic dysfunction, etc) by using rodent models that develop obesity and insulin resistance
through direct genetic manipulation or exposure to high fat diets. Thus, through rigorous in vivo metabolic
phenotyping in conjunction with detailed mechanistic analysis of relevant tissues by NORC investigators, the
AMPC helps all NORC projects address the critical unanswered question of how an obesogenic environment
affects normal metabolism at the whole body level.

## Key facts

- **NIH application ID:** 9923631
- **Project number:** 5P30DK072476-15
- **Recipient organization:** LSU PENNINGTON BIOMEDICAL RESEARCH CTR
- **Principal Investigator:** Randall Lee Mynatt
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $274,595
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9923631

## Citation

> US National Institutes of Health, RePORTER application 9923631, Animal Models & Phenotyping Core (5P30DK072476-15). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/9923631. Licensed CC0.

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