# Diurnal rhythm in nutrient metabolism for metabolic homeostasis

> **NIH NIH R01** · SALK INSTITUTE FOR BIOLOGICAL STUDIES · 2020 · $673,400

## Abstract

Abstract
Disruption in metabolic homeostasis is increasingly recognized as the root cause of obesity, insulin resistance,
nonalcoholic steatohepatitis, hyperlipidemia, and cardiovascular diseases. Current efforts on prevention and
therapies are focused on key components that mediate nutrient utilization, interconversion and storage.
However, metabolic diseases are complex in nature with disruption in multiple pathways, often requiring
progressively more complex combination therapies. Novel intervention that is effective both as a preventative
method and to augment therapy is urgently needed. The circadian regulation of metabolism and physiology
offer a novel promising avenue for the prevention and the treatment of these diseases. There is growing
evidence that disruption of natural circadian rhythm in sleep and nutrition as occurs in people doing shiftwork is
associated with increased incidence of metabolic diseases in humans. Furthermore, even among the general
population, the daily rhythm of sleep and nutrition is significantly disrupted. Therefore, behavioral changes that
sustain robust circadian function are considered to be beneficial against challenges that predispose to
metabolic diseases. Time-restricted feeding (TRF), in which animals are fed within an 8-12 hour time interval
during their natural circadian wakeful hours is both preventative and therapeutic against metabolic diseases in
both mice and insects. There is growing precedence that the time of food intake has a profound impact on
body weight regulation in humans. While these preliminary findings are encouraging, major questions remain
to be answered before any potential human translation. Is TRF beneficial under a shiftwork paradigm that
chronically disrupts circadian rhythm? And what are the potential mechanisms underlying TRF benefits? This
proposal will test these questions in mice that are effectively used to model circadian rhythm disruption and
metabolic diseases.

## Key facts

- **NIH application ID:** 9923646
- **Project number:** 5R01DK115214-03
- **Recipient organization:** SALK INSTITUTE FOR BIOLOGICAL STUDIES
- **Principal Investigator:** Satchidananda Panda
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $673,400
- **Award type:** 5
- **Project period:** 2018-05-10 → 2021-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9923646

## Citation

> US National Institutes of Health, RePORTER application 9923646, Diurnal rhythm in nutrient metabolism for metabolic homeostasis (5R01DK115214-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9923646. Licensed CC0.

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