# A Genome-Wide Analysis of Nociception Molecules, from Expression to Function

> **NIH NIH R01** · TRUSTEES OF INDIANA UNIVERSITY · 2020 · $350,954

## Abstract

Project Summary Abstract
This project seeks to identify new molecular pathways that are involved in pain signaling.
The PI has pioneered a system that uses Drosophila as a platform for discovering genes
required for the function of nociceptive sensory neurons. Understanding molecular
mechanisms in nociceptors is of significance because sensory drive in nociceptors
contributes to the development of central sensitization and subsequent chronic pain.
Furthermore, congenital pain syndromes are caused by mutations in genes that affect
the function of nociceptive sensory afferents in humans. Thus, a fundamental and basic
understanding of the molecular mechanisms of nociceptive neurons is important for an
understanding of chronic, neuropathic, and inflammatory pain. The laboratory of the PI
has conducted a genetic screen which has led to the identification of a set of genes that
are of importance to the function of nociceptive neurons. During the funding period
experiments will be performed that seek to elucidate the molecular, cellular and
physiological mechanisms of these newly implicated molecules.

## Key facts

- **NIH application ID:** 9923647
- **Project number:** 5R01GM086458-09
- **Recipient organization:** TRUSTEES OF INDIANA UNIVERSITY
- **Principal Investigator:** William D Tracey
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $350,954
- **Award type:** 5
- **Project period:** 2011-07-05 → 2021-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9923647

## Citation

> US National Institutes of Health, RePORTER application 9923647, A Genome-Wide Analysis of Nociception Molecules, from Expression to Function (5R01GM086458-09). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/9923647. Licensed CC0.

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