# Core C - Melanoma Screening and Stratification

> **NIH NIH P01** · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2020 · $222,486

## Abstract

SUMMARY – CORE C: MELANOMA SCREENING AND STRATIFICATION 
The focus of this P01 is the biological interplay between metabolism, endoplasmic reticulum (ER) stress, and 
mitochondrial biogenesis and function in melanoma. Alterations in these functions may promote therapeutic 
resistance and at the same time create novel drug sensitivities. Thus, a goal of the P01 will be to understand 
the mechanisms underlying deregulation of central metabolism, ER stress pathways, and mitochondrial 
biogenesis and function, and their significance for melanoma development and response to therapy. These 
studies will provide the basis for melanoma stratification based on changes in pathway activities, independent 
of the BRAF and NRAS genotypes. The extensive collaboration among all programs and cores using well- 
annotated melanoma cultures and tissues is essential for success of the P01. Core C will play a critical role in 
association with Projects 1, 2, and 3 and Core B to achieve the goals of the P01. First, we will provide 
biomaterials (melanoma cell cultures and tissue) for experimental use by each of the projects. Second, the 
core will also carry out single-agent and combination high-throughput screening for sensitivity of melanoma to 
select therapeutic agent libraries developed by the core. Third, we will integrate drug sensitivity data with 
genetic, transcriptomic, and proteomic data on the cell cultures and tissues to be analyzed. Finally, we will 
provide comprehensive pathology support and access to clinically annotated archival human melanoma tissue 
for translational studies.

## Key facts

- **NIH application ID:** 9925087
- **Project number:** 5P01CA128814-10
- **Recipient organization:** SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- **Principal Investigator:** DAVID F STERN
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $222,486
- **Award type:** 5
- **Project period:** — → 2021-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9925087

## Citation

> US National Institutes of Health, RePORTER application 9925087, Core C - Melanoma Screening and Stratification (5P01CA128814-10). Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/grant/nih/9925087. Licensed CC0.

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