# Pathogenesis and therapeutic targeting of immune disorders

> **NIH NIH T32** · CINCINNATI CHILDRENS HOSP MED CTR · 2020 · $131,538

## Abstract

Project Summary/Abstract
Dysregulated immune responses are of central importance to the pathogenesis and expression of a wide
spectrum of diseases that cause an immense burden of morbidity and mortality. The overall Aim of the training
grant is to provide training for 3 pre-doctoral candidates, whose research will uncover pathogenic mechanisms
of immune-mediated disease and facilitate transformative therapeutic approaches, consistent with the mission
of the NIH. Candidates will be recruited from the Immunology Graduate Program (ImmGP) and the Medical
Scientist Training Program at Cincinnati Children’s Hospital Medical Center (CCHMC) and the University of
Cincinnati College of Medicine (UCCOM). Housed within CCHMC, one of the premiere pediatric research
institutions in the US, the ImmGP attracts a strong and diverse pool of applicants. ImmGP students receive
exemplary didactic instruction in immunology, research ethics, grant writing, and biostatistics. The training
program will be led by a Director and Co-Director (Drs. Hildeman and Singh) who, along with 34 outstanding
Training Faculty (TF), have significant experience in mentoring pre-doctoral students. Students will work with a
diverse group of TF (comprised of MDs, MD/PhDs, and PhDs), from multiple departments at CCHMC/UCCOM,
who share a collective focus on the mechanistic understanding of the immunologic basis of human disease.
Students in this training program will be immersed in a distinctive environment: TF have well-funded research
programs that span basic immunology to animal models of disease to clinical trials in human patients; CCHMC
provides tremendous institutional resources (e.g., support for graduate education and faculty research, cutting-
edge core facilities, unique patient cohorts); a collaborative research student exchange program with a
German University and Research Institute provides a unique opportunity for international studies in
immunology. Graduates of this program will be uniquely poised to bring innovations in immunology from the
laboratory bench to the bedside and will be well-prepared for independent research careers.

## Key facts

- **NIH application ID:** 9925180
- **Project number:** 5T32AI118697-05
- **Recipient organization:** CINCINNATI CHILDRENS HOSP MED CTR
- **Principal Investigator:** David A Hildeman
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $131,538
- **Award type:** 5
- **Project period:** 2016-07-01 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9925180

## Citation

> US National Institutes of Health, RePORTER application 9925180, Pathogenesis and therapeutic targeting of immune disorders (5T32AI118697-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9925180. Licensed CC0.

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