# Physical Resources Core

> **NIH NIH P01** · DUKE UNIVERSITY · 2020 · $676,475

## Abstract

Core 001. Physical Resources Core
 The purpose of this core is to provide common physical materials needed by the projects and cores of this
program in support of the overall goals. The overall Program hypothesis is that the RM model can be
substantially improved for testing antibody-based interventions and vaccines through elucidation of key
variables that impact species-specific FcgR-dependent effector functions (i.e. antibody epitope specificity,
immune complex formation, isotype/subclass, glycosylation, and FcR genotype/phenotype. The Physical
Resources Core will support Projects 1, 2, 3 (P1, P2, P3) and Core 2 (C2) and play a key role in achieving
Program Goals by providing physical materials to Program components to facilitate the characterization of RM
FcRs and effector cell biology across humans and RM.
 Drs. Moody, Saunders and Shaw have long-standing collaborations as part of the Duke Human Vaccine
Institute and work together seamlessly in combining their expertise for provision of materials to collaborators.
These materials include human clinical samples and corresponding materials from rhesus macaques for
comparison, as well as SHIVs, and will be distributed among all three projects.
The specific aims for Core 001 are as follows:
AIM 1. Produce and distribute recombinant FcR proteins, membrane bound FcR proteins in virus-like
particles and cell lines expressing full-length receptors.
AIM 2. Produce and distribute viral proteins, RM and human antibodies, and virus stocks.
AIM 3. Create and maintain a repository of human and RM PBMCs.

## Key facts

- **NIH application ID:** 9925741
- **Project number:** 5P01AI120756-05
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Michael Anthony Moody
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $676,475
- **Award type:** 5
- **Project period:** — → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9925741

## Citation

> US National Institutes of Health, RePORTER application 9925741, Physical Resources Core (5P01AI120756-05). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/9925741. Licensed CC0.

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