# Analytical Resources Core

> **NIH NIH P01** · DUKE UNIVERSITY · 2020 · $854,035

## Abstract

ABSTRACT: Core 2. Analytical Resources Core
The Analytical Resources Core (Core 2) will contribute to the overall Program goals and to each Project by
exploring the specific hypothesis that the structural and biophysical/chemical features of antibody recognition
will define mechanisms associated with potent or weak effector function and similarities and differences in
antibody biology between species relevant to vaccine and antibody therapy outcomes. The Core will provide
key services for biophysical, biochemical, and structural characterization of Ab interactions, complemented by
central analysis of data collected through Projects 1, 2, and 3, for synthesis to define key similarities and
differences between NHP and humans in terms of Ab and effector cell biology. The specific aims of this core
are as follows:
AIM 1. Determine and optimize FcR binding profiles of Program antibodies and immune complexes.
AIM 2. Determine co-crystal structures of relevant Program Ab:antigen and Ab:Fc receptor pairs.
AIM 3. Model the knowledge of paratope and Fc function to define optimal antibody features for Fc-
mediated antiviral activities.
Through these aims, this Core will serve the needs of all three Projects and provide key contributions to
achieving the shared goals of this Program.

## Key facts

- **NIH application ID:** 9925742
- **Project number:** 5P01AI120756-05
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Nathan A Vandergrift
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $854,035
- **Award type:** 5
- **Project period:** — → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9925742

## Citation

> US National Institutes of Health, RePORTER application 9925742, Analytical Resources Core (5P01AI120756-05). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/9925742. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*