# Antibody Cooperation mediated by Fc-gamma Receptor (FcyR)-bearing cells

> **NIH NIH P01** · DUKE UNIVERSITY · 2020 · $726,844

## Abstract

Project 2. Antibody Cooperation for Fc-Fc-gamma Receptor (FcγR)-mediated functions.
Although intrinsic differences in Fc-FcR interactions exist between humans and RM, we hypothesize that
similarities between the two species for engagement of the FcγR-bearing cells can be defined to 1)
select RM with FcγR genotypes/phenotypes mediating antiviral functions that match those observed in
humans; and 2) identify combinations of antibodies of multiple specificities, through highly selective Fc-
FcγR antibody interactions, that can act in concert to recruit Fc-gamma R-bearing cells similar to humans
The overall Program hypothesis is that the RM model can be substantially improved for testing antibody-based
interventions and vaccines through elucidation of key variables that impact species-specific FcgR-dependent
effector functions (i.e. antibody epitope specificity, immune complex formation, isotype/subclass, glycosylation,
and FcR genotype/phenotype.
The specific aims for Project 2 are as follows:
AIM 1. Define similarities and differences in FcγR mediated Ab effector function between RM and
humans.
AIM 2. Determine the combination of antibodies that together can mediate superior antiviral function

## Key facts

- **NIH application ID:** 9925744
- **Project number:** 5P01AI120756-05
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Guido Ferrari
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $726,844
- **Award type:** 5
- **Project period:** — → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9925744

## Citation

> US National Institutes of Health, RePORTER application 9925744, Antibody Cooperation mediated by Fc-gamma Receptor (FcyR)-bearing cells (5P01AI120756-05). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/9925744. Licensed CC0.

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