# Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic Resolution

> **NIH NIH R35** · UNIVERSITY OF VIRGINIA · 2020 · $675,403

## Abstract

Abstract
We aim to greatly extend our existing studies in the two current R01s (Actin and Nucleoprotein
Complexes) in the proposed period, capitalizing on the advances in electron cryo-microscopy
that have only recently become possible with direct electron detectors. In addition, we will work
on a number of projects that are outside the scope of the present R01s, but involve bacterial
pathogenesis and thus have great relevance to human health: Type IV pili, Type II Secretion
System, bacterial and archaeal flagellar filaments. By working on many disparate polymers, we
expect to develop more general methods that can be applied by others to helical polymers in
biology. Since large numbers of such polymers exist, ranging from cytoskeletal filaments to
amyloid to helical viruses (such as Ebola), the potential significance of this work is enormous
and likely to have a great impact.

## Key facts

- **NIH application ID:** 9925804
- **Project number:** 5R35GM122510-04
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** EDWARD H. EGELMAN
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $675,403
- **Award type:** 5
- **Project period:** 2017-05-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9925804

## Citation

> US National Institutes of Health, RePORTER application 9925804, Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic Resolution (5R35GM122510-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9925804. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*