# Methods for Selective Organic Synthesis based on Ionic Catalysts

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA BERKELEY · 2020 · $51,331

## Abstract

Project Summary
The  major  goal  of  this  research  program  is  to  develop  catalytic  enantioselective 
transformations based on transition metal and chiral anion catalysis that will be broadly 
applicable to the preparation of therapeutically relevant organic molecules. Towards this 
end,  new  enantioselective  reactions  of  carbon-­‐‑carbon  π-­‐‑bonds  are  proposed,  with  a 
major  emphasis  placed  on  the  development  of  enantioselective  sp3-­‐‑C-­‐‑F  bond 
construction.  Additionally,  reactions  that  generate  or  employ  available  building  blocks, 
such  as  alkenes  and  boronic  acids,  will  be  targeted.  These  methods  will  be  exploited  in 
the enantioselective construction of fluorinated building blocks, heterocycles and natural 
product  analogs.    Thus,  we  anticipate  that  the  proposed  air  and  moisture  tolerant 
transformations  will  provide  synthetic  chemists  and  biomedical  researchers  with 
additional tools for molecular synthesis and for single enantiomer construction.

## Key facts

- **NIH application ID:** 9926044
- **Project number:** 3R35GM118190-04S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** F. Dean Toste
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $51,331
- **Award type:** 3
- **Project period:** 2016-06-03 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9926044

## Citation

> US National Institutes of Health, RePORTER application 9926044, Methods for Selective Organic Synthesis based on Ionic Catalysts (3R35GM118190-04S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9926044. Licensed CC0.

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